外周起源的运动障碍疾病研究进展

Research progress of peripherally-induced movement disorder

外周起源的运动障碍疾病是指在非中枢神经系统损伤后出现不自主运动症状的一组运动障碍疾病。其临床表现包括不自主运动增多和运动减少,可累及全身多个部位。该病的诊断主要依靠外周损伤与运动障碍发生的时间和空间关系。目前该病的病因、发病机制及治疗策略尚存争论。文中对外周起源的运动障碍疾病的临床表现、分类、诊断、鉴别诊断、治疗策略及潜在发病机制进行综述,旨在增加临床医师对疾病的认识,避免在临床诊疗中出现漏诊和误诊。

Peripherally-induced movement disorders(PIMD)are a group of involuntary movements that emerge after an injury to a body part outside the central nervous system.The phenomenology of PIMD encompasses both hyperkinesia and hypokinesia involving multiple parts of the body.The diagnosis of this disease mainly relies on the temporal and spatial relationship between peripheral injuries and movement disorders.The etiology,pathogenesis and treatment of PIMD have been a matter of debate.This article will review the clinical features,classification,diagnosis,treatment and possible pathogenesis of PIMD,and discuss the limitations and controversies of PIMD-related researches,aiming to advance the understanding of PIMD and avoid clinical misdiagnosis.