α-亚麻酸对肌萎缩侧索硬化的神经保护作用研究进展

Research progress in the neuroprotective effect ofα-linolenic acid on amyotrophic lateral sclerosis

肌萎缩侧索硬化是大脑和脊髓运动神经元缺失导致的一种致命性神经退行性疾病。肌萎缩侧索硬化目前无法治愈,治疗药物效果局限且只能延缓病情。最新研究表明α-亚麻酸能延长肌萎缩侧索硬化患者的生存期。文中围绕α-亚麻酸在肌萎缩侧索硬化中通过不同的作用机制来发挥神经保护作用等方面作一综述,旨在为肌萎缩侧索硬化的治疗提供一定的参考。

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease caused by the loss of motor neurons in the brain and spinal cord.Amyotrophic lateral sclerosis is currently incurable and treatment drugs are limited and can only delay the condition.The latest research shows thatα-linolenic acid can prolong the survival period of patients with amyotrophic lateral sclerosis.This article reviews the neuroprotective effects ofα-linolenic acid on amyotrophic lateral sclerosis through different mechanisms of action,aiming at providing some references for the treatment of amyotrophic lateral sclerosis.