循环肿瘤细胞用于肝细胞癌精准动态监测的临床应用进展

Clinical application progress of circulating tumor cells for accurate dynamic monitoring of hepatocellular carcinoma

肝细胞癌(hepatocellular carcinoma,HCC)是最常见的恶性肿瘤之一,也是癌症相关死亡的主要原因。目前没有理想的生物标志物可以对接受治疗的HCC患者进行早期诊断和肿瘤监测。循环肿瘤细胞(circulating tumor cell,CTC)已成为在非侵入性环境中进行诊断和监测不同肿瘤治疗反应的有用工具,在HCC患者精准医疗应用方面具有巨大潜力。本文对CTC在指导HCC手术方式、切缘及介入治疗和系统药物治疗等精准动态监测应用中的研究进展进行综述。

Hepatocellular carcinoma(HCC)is the fifth most common neoplasm and a major cause of cancer-related death worldwide.There is no ideal biomarker allowing early diagnosis of HCC and tumor surveillance in patients receiving therapy.Circulating tumor cells(CTC)have become a useful tool for diagnosing and monitoring therapeutic responses of different tumors in a non-invasive setting,and have great potential for precision medicine delivery in HCC patients.Based on existing clinical application evidence,this review will discuss the application and research progress of CTC in guiding surgical methods,resection margins,interventional therapy and systematic therapy,and other accurate dynamic monitoring.