CXCL趋化因子在头颈部鳞状细胞癌中的表达及临床意义

Effect of CXCL chemokines on the diagnosis and prognosis of head and neck quamous cell carcinoma

目的探讨CXCL趋化因子家族在头颈部鳞状细胞癌(HNSCC)中的表达及作为其诊断与预后标志物的价值。方法利用公共数据库,分析HNSCC中异常表达的CXCL因子类型以及与HNSCC患者不良预后的相关性,计算CXCL家族与免疫因子浸润的相关性。结果与正常组织相比,CXCL在HNSCC组织及病理分期中存在差异表达,且与HNSCC患者更长的总生存期(OS)及免疫细胞浸润密切相关;CXCL趋化因子在HNSCC中基因功能主要富集在趋化因子活性等;KEGG通路主要富集细胞因子-细胞因子受体相互作用等;CXCL家族在HNSCC中有一定的突变率。结论基于肿瘤生物信息学分析发现,CXCL家族在HNSCC组织中的表达水平与正常组织有差异,且其表达水平与免疫细胞浸润以及肿瘤预后具有相关性,可作为HNSCC预后标志物以及基因治疗靶点。

Objective This study investigated the expression levels of CXCL chemokines in head and neck cancer and their value as diagnostic and prognostic markers.Methods Public databases were used in the analysis of various abnormally expressed CXCL factors in head and neck cancer and their correlation with the poor prognoses of patients with head and neck cancer,and the correlation between CXCL family and immune factor infiltration was determined.Results Compared with normal tissues,CXCL is differentially expressed in head and neck squamous cell carcinoma(HNSCC)tissues and pathological stages,and it is closely related to long overall survival(OS)and immune cell infiltration in patients with HNSCC.CXCL chemokine gene function in HNSCC is mainly concentrated in chemokine activity.The KEGG pathway is mainly concentrated in cytokine-cytokine receptor interaction,and the CXCL family has a certain mutation rate in HNSCC.Conclusion Tumor bioinformatics analysis showed that the expression levels of the CXCL family in HNSCC tissues are different from those in normal tissues and correlated with immune cell infiltration and tumor prognosis,showing potential as prognostic markers for HNSCC and gene therapy targets.