误诊为持久性隆起性红斑的海分枝杆菌感染一例

Mycobacterium marinum infection misdiagnosed as persistent erythema protuberant:a case report

患者,女,48岁。左膝结节16个月。患者曾在外院接受伊曲康唑及氨苯砜治疗9个月,无效。患者在我院通过皮肤组织分枝杆菌培养和定量聚合酶链反应(qPCR)测序技术诊断为海分枝杆菌感染,口服利福平和克拉霉素治疗4个月,皮损明显好转。患者从出现皮肤症状到诊断为海分枝杆菌感染的时间为16个月,提醒皮肤科临床医生应注意海分枝杆菌感染的非典型临床表现。

A 48-year-old female presented with nodules on the left knee for 16 months.The patient had been treated with itraconazole and dapsone in another hospital for 9 months,with ineffective.The patient was diagnosed with Mycobacterium marine infection by mycobacterium culture and quantitative polymerase chain reaction(qPCR)technique of skin tissue in our hospital.After 4 months of oral rifampicin and clarithromycin,the skin lesions were significantly improved.The time from the onset of skin symptoms to the diagnosis of mycobacterium marine infection was 16 months,which reminds dermatologists should be aware of the atypical clinical manifestations of Mycobacterium marinum infection.