莫沙必利片联合奥美拉唑镁肠溶片治疗质子泵抑制药-难治性胃食管反流病的效果

Effect of Mosapride Tablets Combined with Omeprazole Magnesium Enteric-coated Tablets in Proton Pump Inhibitors-refractory Gastroesophageal Reflux Disease

目的:观察莫沙必利片联合奥美拉唑镁肠溶片治疗质子泵抑制药(PPI)-难治性胃食管反流病的效果。方法:选取2020年11月—2021年11月本院诊治的92例PPI-难治性GERD患者作为研究对象。根据随机数字表法将患者分为研究组(n=46)和参照组(n=46)。参照组仅采取莫沙必利片治疗,研究组采取莫沙必利片联合奥美拉唑镁肠溶片治疗,比较两组临床疗效、症状积分、反流情况、炎症因子水平、不良反应及复发情况。结果:研究组治疗总有效率高于参照组(P<0.05);研究组RSI、RFS评分低于参照组(P<0.05);研究组胸骨后疼痛、反酸、胃灼热、胃脘灼痛症状积分低于参照组(P<0.05);研究组TNF-α、hs-CRP、IL-6水平低于参照组(P<0.05);研究组不良反应发生率、复发率低于参照组(P<0.05)。结论:莫沙必利片联合奥美拉唑镁肠溶片治疗PPI-难治性GERD患者具有较为理想的效果,可减轻反流程度,改善疾病症状,同时还可改善机体炎症反应,降低不良反应与复发风险。

Objective:To observe the effect of mosapride tablets+omeprazole magnesium enteric-coated tablets in the treatment of proton pump inhibitor(PPI)-refractory gastroesophageal refux disease.Methods:A total of 92 patients with PPI-refractory GERD diagnosed and treated in our hospital from November 2020 to November 2021 were selected as the study subjects.According to the random number table method,the patients were divided into study group(n=46)and reference group(n=46).The reference group was only treated with mosapride tablets,and the study group was treated with mosapride tablets+omeprazole magnesium enteric-coated tablets.The clinical efficacy,symptom scores,reflux,inflammatory factor levels,adverse reactions and recurrence were compared between the two groups.Results:The total effective rate of treatment in the study group was higher than that in the reference group(P<0.05).The RSI and RFS scores of the study group were lower than those of the reference group(P<0.05).The scores of substernal pain,acid reflux,heartburn and epigastric burning pain in the study group were lower than those in the reference group(P<0.05).The levels of TNF-α,hs-CRP and IL-6 in the study group were lower than those in the reference group(P<0.05).The incidence of adverse reactions and recurrence rate in the study group were lower than those in the reference group(P<0.05).Conclusion:Mosapride tablets and omeprazole-magnesium enteric-coated tablets have an ideal effect in the treatment of PPIrefractory GERD patients,which can reduce the degree of reflux,improve the symptoms of the disease,improve the inflammatory response of the body,and reduce the risk of adverse reactions and recurrence.