西格列汀治疗胰岛素治疗效果不佳的2型糖尿病患者的效果

The Effect of Sitagliptin in the Treatment of Type 2 Diabetic Patients with Poor Insulin Therapy

目的:探讨西格列汀治疗胰岛素效果欠佳的2型糖尿病(T2DM)患者的效果及对胰岛B细胞功能的影响。方法:选取2020年7月—2022年7月本院收治的126例胰岛素治疗效果欠佳的T2DM患者,按照随机数字表法分为对照组和观察组,每组63例。两组均给予胰岛素(每日30U)基础治疗,对照组给予二甲双胍治疗,观察组给予西格列汀治疗,比较两组血糖水平、胰岛功能水平、血脂水平及不良反应发生情况。结果:治疗3个月后,观察组空腹血糖(FPG)、餐后2h血糖(2hPG)、胰岛素抵抗指数(HOMA-IR)、总胆固醇(TC)、三酰甘油(TG)低于对照组,胰岛B细胞功能水平(HOMA-B)高于对照组(P<0.05);观察组不良反应发生率为12.69%,低于对照组的26.98%(P<0.05)。结论:将西格列汀用于胰岛素治疗效果欠佳的T2DM患者中,有助于改善患者胰岛B细胞功能,降低血糖血脂水平,且不良反应少,安全性高。

Objective:To investigate the effect of sitagliptin in the treatment of type 2 diabetes mellitus(T2DM)patients with poor insulin effect and its effect on islet B cell function.Methods:A total of 126 T2DM patients with poor insulin treatment in our hospital from July 2020 to July 2022 were selected and divided into control group and observation group according to the random number table method,with 63 cases in each group.Both groups were treated with insulin(30 U per day).The control group was treated with metformin,and the observation group was treated with sitagliptin.The blood glucose level,islet function level,blood lipid level and adverse reactions were compared between the two groups.Results:After 3 months of treatment,the fasting blood glucose(FPG),2 h postprandial blood glucose(2hPG),insulin resistance index(HOMA-IR),total cholesterol(TC)and triglyceride(TG)in the observation group were lower than those in the control group,and the islet B cell function level(HOMA-B)was higher than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was 12.69%,which was lower than 26.98% in the control group(P<0.05).Conclusion:The application of sitagliptin in T2DM patients with poor insulin treatment is helpful to improve islet B cell function,reduce blood glucose and blood lipid levels,and has fewer adverse reactions and high safety.