清热调血汤联合穴位敷贴辅助治疗慢性盆腔炎的效果观察

Observation on the Effect of Qingre Tiaoxue Decoction Combined with Acupoint Application in the Treatment of Chronic Pelvic Inflammatory Disease

目的:探究清热调血汤加减、穴位敷贴辅助治疗湿热瘀结型慢性盆腔炎(CPID)患者的效果。方法:收集2020年3月—2022年3月本院104例湿热瘀结型CPID患者,按治疗方案不同分成中西结合组(n=52)和西医组(n=52)。西医组接受口服头孢羟氨苄(CEX)治疗,中西结合组于西医组基础上配以清热调血汤加减、穴位敷贴辅助治疗。比较两组总有效率、中医证候积分、视觉模拟评分法(VAS)评分、炎症指标[转化生长因子-β1(TGF-β1)、单核细胞趋化蛋白-1(MCP-1)、血红素氧和酶-1(HO-1)]、氧化应激指标[超氧化物歧化酶(SOD)、活性氧(ROS)、谷胱甘肽过氧化物酶(GSH-Px)]水平。结果:中西结合组治疗总有效率为92.31%,高于西医组的76.92%(P<0.05);中西结合组中医证候积分、VAS评分低于西医组(P<0.05);中西结合组血清MCP-1、HO-1、ROS水平低于西医组,血清TGF-β1、SOD、GSH-Px水平高于西医组(P<0.05)。结论:清热调血汤加减、穴位敷贴辅助CEX治疗湿热瘀结型CPID患者疗效显著,可有效缓解疼痛感,促进病情改善,同时能进一步减轻机体炎性反应,缓解氧化应激状态。

Objective:To explore the effect of Qingre Tiaoxue Decoction and acupoint application in the treatment of patients with chronic pelvic inflammatory disease(CPID)of damp-heat stasis type.Methods:A total of 104 patients with CPID of damp-heat stasis type in our hospital from March 2020 to March 2022 were collected and divided into integrated Chinese and western medicine group(n=52)and western medicine group(n=52)according to different treatment schemes.The western medicine group was treated with oral cefalexin(Cefalexin,CEX),and the combination group was treated with Qingre Tiaoxue decoction and acupoint application on the basis of the western medicine group.The total effective rate,TCM syndrome score,visual analogue scales(VAS)score,inflammatory indexes[transforming growth factor beta-1(TGF-β1),monocyte chemoattractant protein-1(MCP-1),heme oxygenase-1(HO-1)],oxidative stress indexes[superoxide dismutase(SOD),reactive oxygen species(ROS),glutathione peroxidase(GSH-Px)]were compared between the two groups.Results:The total effective rate of the combination group was 92.31%,which was higher than 76.92% of the western medicine group(P<0.05).The TCM syndrome score and VAS score of the integrated Chinese and Western medicine group were lower than those of the Western medicine group(P<0.05).The levels of serum MCP-1,HO-1 and ROS in the combination group were lower than those in the western medicine group,and the levels of serum TGF-β1,SOD and GSH-Px were higher than those in the western medicine group(P<0.05).Conclusion:Modified Qingre Tiaoxue decoction and acupoint application assisted CEX in the treatment of CPID patients with damp-heat stasis syndrome have significant curative efect,which can effectively relieve pain and promote the improvement of the disease.At the same time,it can further reduce the body's inflammatory response and relieve oxidative stress.