基于中医传承辅助平台分析王孟清教授治疗儿童哮喘缓解期用药规律

An analysis of Professor WANG Mengqing’s medication rule in treating childhood asthma during the remission period based on the Traditional Chinese Medicine Inheritance Support System

目的:采用中医传承辅助平台分析了王孟清教授治疗儿童哮喘缓解期处方,归纳总结了王孟清教授治疗儿童哮喘缓解期用药规律,以期为临床提供参考。方法:收集2022年6月-2023年6月王孟清教授于湖南中医药大学第一附属医院儿科门诊诊疗的哮喘缓解期有效病历。采用中医传承辅助平台统计分析药物的使用频次、常用药物组合、性味、核心药物组合及新处方。结果:共纳入处方149首,涉及中药97味,前10位的依次为白术、茯苓、山药、太子参、黄芪、黄芩、防风、麦冬、甘草、鸡内金、五味子,有22味使用频次大于30的药物;药性使用频率最高的为温,其次为平、寒;药味使用频率最高的为甘,其次为苦、辛;药物归经前4位为肺经、脾经、胃经、肾经。常用药物组合40对,其中包含麦冬、太子参、白术、山药、茯苓、黄芪、黄芩、防风8味中药,出现频次最高的是黄芪、白术。得到3首新处方:(1)黄精、法半夏、甘草、陈皮、熟地黄;(2)法半夏、当归、甘草、陈皮、熟地黄;(3)茯苓、生地黄、太子参、麻黄根、浮小麦。结论:王教授治疗儿童哮喘缓解期组方符合肺、脾、肾同治,全面兼顾,扶正固本的原则。

Objective:To analyze the 149 prescriptions of Professor WANG Mengqing in treating childhood asthma during the remission period based on the Traditional Chinese Medicine Inheritance Support System(V2.5),and summarize the medication rule of Professor WANG Mengqing in the treatment of childhood asthma during the remission period,in order to provide clinical reference.Methods:Effective medical records of asthma remission period treated by Professor WANG Mengqing at the Pediatric Outpatient Department of the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine from June 2022 to June 2023 were collected.Traditional Chinese Medicine Inheritance Support System was used to statistically analyze the use frequency of drugs,commonly used drug combinations,medical properties and tastes,core drug combinations,and new prescriptions.Results:A total of 149 prescriptions were included,involving 97 traditional Chinese medicines.The top 10 were Baizhu(Rhizoma Atractylodis Macrocephalae),Fuling(Poria),Shanyao(Rhizoma Dioscoreae),Taizishen(Radix Pseudostellariae),Huangqi(Radix Astragali),Fangfeng(Radix Saposhnikoviae),Maidong(Radix Ophiopogoni),Gancao(Radix Glycyrrhizae),Jineijin(Endothelium Corneum Gigeriae Galli),and Wuweizi(Fructus Schisandrae Chinensis),and there were 22 drugs with a use frequency of greater than 30 times.Warm drugs were used most frequently,followed by calmness and coldness.The most frequently used medicinal taste is sweet,followed by bitter and spicy.The top four meridians for medication were the lung meridian,spleen meridian,stomach meridian,and kidney meridian.There were 40 pairs of commonly used drug combinations,including Maidong,Taizishen,Baizhu,Shanyao,Fuling,Huangqi,Huangqin and Fangfeng,Huangqi and Baizhu showed the highest frequency.Three new prescriptions were obtained:①Huangjing(Rhizoma Polygonati),Fabanxia(Rhizoma Pinelliae Preparatum),Gancao,Chenpi(Pericarpium Citri Reticulatae),Shudihuang(Radix Rehmanniae Preparata).②Fabanxia,Danggui(Radix Angelicae Sinensis),Gancao,Chenpi,Shudihuang.③Fuling,Shengdihuang(Radix Rehmaniae Recens),Taizishen,Mahuanggen(Radix Ephedrae),Fuxiaomai(Fructus Tritici Levis).Conclusion:Professor WANG’s prescriptions for treating children asthma in the remission stage is in line with the principle of treating the lungs,spleen,and kidneys simultaneously,comprehensively considering the needs of the body,and strengthening the foundation.