调节肠道微生态治疗功能性便秘的研究进展

Research Progress in Regulating Intestinal Microecology in the Treatment of Functional Constipation

功能性便秘属于慢性胃肠疾病,主要临床表现为排便费时费力、次数减少和便后不爽。近年来,生活方式改变伴随着功能便秘全球发病率逐年递增,增加了内分泌、心血管、肛肠及精神疾病患病的风险,并降低患者食欲、生活质量,影响工作效率及心理健康。肠道微生态失衡在FC的发展中发挥着非常重要的作用,在治疗FC时恢复肠道菌群平衡对于改善便秘相关症状有着非常重要的意义。应用粪菌移植、微生态制剂及中医药调节肠道微生态是治疗FC的研究热点。

Functional constipation is a chronic gastrointestinal disease,and the main clinical manifestations are time-consu-ming and laborious bowel movements,reduced frequency and unhappiness after stool.In recent years,lifestyle changes have in-creased the global incidence of functional constipation,increasing the risk of endocrine,cardiovascular,anorectal and psychiatric diseases,reducing patients'appetite and quality of life,and affecting work efficiency and mental health.Therefore,its treatment research has risen to the top of the hot spot.More and more research data show that intestinal microbiome imbalance plays a very important role in the development of FC,and it is of great significance to effectively restore the balance of intestinal flora in pa-tients during the treatment of FC to improve the symptoms related to constipation.The objective of this review was to summarize the application and latest progress of the regulation of intestinal microbiome therapy FC through fecal bacteria transplantation,mi-croecological preparations and traditional Chinese medicine.