基于CiteSpace分析我国中医药领域乳腺癌治疗的研究热点及趋势

Visual Analysis on Research Hotspot and Trend of Breast Cancer in Traditional Chinese Medicine Based on Cite Space Visualization

目的利用CiteSpace 5.8软件分析中国中医药领域乳腺癌治疗近20年来的研究热点和趋势,探究其未来发展方向。方法在中国期刊网数据库(CNKI)中对2000年1月—2022年4月的中医药领域乳腺癌治疗文献进行检索,以“乳腺癌”和“中医药”为主题,导入NoteExpress软件,然后根据纳入和排除标准进行人工检索,以Refworks格式导入CiteSpace 5.8软件,以该软件来可视化分析纳入文献的作者、机构、关键词及其他信息。结果共收录2207篇论文,文献数量总体呈现出上升趋势,核心作者58人,发文最多的作者为刘胜,作者团队内部合作较稳定,但团队之间合作较少。研究机构主要在中医药类高校,各机构间联系相对紧密,呈现出一定地域性。相关关键词主要为化疗、生活质量、中药、凋亡等,关键词聚类共有95个,前十个聚类涵盖临床试验、动物实验和机制研究以及药物实验,关键词凸现前18个关键词表明,最近的研究热点集中在“免疫功能”“疗效”“自噬”方面。结论中医药领域乳腺癌治疗的相关研究成果丰富而广泛,研究热点主要集中在中医药应用提高乳腺癌患者的生活质量、提高免疫功能、辅助化疗和细胞凋亡机制。而细胞自噬和免疫功能的研究为近年来的研究前沿,这为该领域未来研究提供了方向,但仍需要更多高质量研究支持。

Objective To analyze the research hotspot and trend of breast cancer treatment in traditional Chinese medicine(TCM)over the past 20 years using CiteSpace 5.8 software and explore its future development direction.Methods A search of the literature on breast cancer treatment in TCM from January 2000 to April 2022 was conducted in the China Journal Network data-base(CNKI),using"breast cancer"and"TCM"as topics,and imported into NoteExpress.The search was then conducted man-ually according to the inclusion and exclusion criteria and imported into CiteSpace 5.8 software in Refworks format,which was used to visually analyze the authors,institutions,keywords and other information of the included papers.Results A total of 2207 papers were included,and the overall number of literature showed an upward trend,with 58 core authors,and the author with the most publications was LIU Sheng,with more stable cooperation within the author team,but less cooperation between teams.The research institutions were mainly in TCM universities,and the connection between institutions was relatively close,showing a cer-tain geography.The relevant keywords were mainly chemotherapy,quality of life,TCM,apoptosis,etc.There were 95 keyword clusters,and the first ten clusters covered clinical trials,experimental and mechanistic studies and drug trials,and the top 18 key-words of keyword emergence indicated that the recent research hotspots were focused on"immune function","therapeutic effica-cy"and"autophagy".Conclusion The research results related to breast cancer treatment in TCM are abundant and extensive,and the research hotspots mainly focus on the application of TCM to improve the quality of life of breast cancer patients,enhance the immune function,adjuvant chemotherapy and apoptosis mechanism.The research on cellular autophagy and immune function has been at the forefront of research in recent years,which provides a direction for future research in this field,but more high-quality research is still needed.