心血管外科术后获得性QT间期延长的研究

Study of acquired QT interval prolongation after cardiovascular surgery

目的 探讨心外科手术与QT间期变化的关系。方法 回顾性分析57例心外科手术和9例大型非心外科手术患者年龄、手术时间、术前QTc、术后QTc、QTc差值的差异性及相关性分析。结果 术中应用体外循环组术后QTc长于非体外循环组。非心外科手术和心外微创手术组QTc差值小于心外科其他手术组。冠脉搭桥数目增多时,术后QTc以及QTc差值也较大。心外手术组手术时间和术后QTc显著相关。结论 心外科手术可引起QT间期较术前延长,特别是在手术时间较长、采用体外循环、冠脉搭桥数目较多时,可引起获得性LQTS的发生。

Objective To explore the relationship between cardiac surgery and QT interval changes.Methods A retrospective analysis was conducted on the differences and correlations in age,operation time,preoperative QTc,postoperative QTc,and QTc difference between 57 cases of extracardiac surgery and 9 cases of major noncardiac surgery.Results The postoperative QTc of the intraoperative cardiopulmonary bypass group was longer than that of the non-cardiopulmonary bypass group.The difference in QTc between non-cardiac surgery and extracardiac minimally invasive surgery groups was smaller than that in other cardiac surgery groups.When the number of bypasses increases,the postoperative QTc and QTc differences also become larger.There was a significant correlation between operation time and postoperative QTc in the extracardiac surgery group.Conclusions Cardiac surgery can cause QT to be longer than preoperative,especially when the longer operation time,extracorporeal circulation,and more bypasses,leading to the occurrence of acquired LQTS.