应对重大新发传染病疫情疫苗研发关键技术选择与建议

Key technology selection for research and development of vaccines for response to emerging pandemic diseases

疫苗接种是人类已知最经济有效的传染病防控手段,是应对全球疾病大流行的优先策略。该研究基于具有典型意义的新型冠状病毒感染(COVID-19)疫苗研发经验,采用文献调研和专家咨询法,筛选了9个疫苗技术子领域30项关键技术,从重要性、紧迫性、创新性和可行性等维度对关键技术进行优先度排序,明确相关技术在技术发展体系中所处的位置,提出应对重大新发传染病疫情的疫苗研发关键技术发展建议,为科研管理部门合理配置科技资源、实现效益最大化提供参考借鉴。

Vaccination is the most cost⁃effective means of prevention and control of infectious diseases,and is a prioritized strategy for responding to pandemic diseases.Based on experience related to research and development of vaccines for coronavirus disease 2019(COVID⁃19),we used literature research and expert consultation methods to screen thirty key technologies in nine sub⁃fields of vaccine technology,which were ranked according to the importance,urgency,innovation and feasibility so as to show where every key technology stood in relation to others in the pineline.The priorities of development of key technologies for vaccines in response to major emerging infectious diseases were recommended to provide reference for related decision⁃makers in their effort to rationalize research resources and maximize the benefits.