TRPV1在鼻高反应性疾病中的作用机制

Research progress on the mechanism of TRPV1in nasal hyperreactive disease

鼻高反应性疾病是临床上常见的上气道疾病,以变应性鼻炎(AR)及血管运动性鼻炎(VMR)为代表,其发病机制复杂,目前的治疗策略仅以改善症状为主,尚不能彻底治愈。近年来研究发现,瞬时受体电位(TRP)家族可能是鼻高反应性疾病治疗的重要靶点。尤其随着对TRP香草酸受体1(TRPV1)研究的不断深入,发现由其主导的神经-免疫调控网络对于鼻高反应性疾病的发生发展有着重要作用。多种药物通过靶向TRPV1,对鼻高反应性疾病显示出良好的治疗效果,反映出TRPV1诱人的临床转化前景。然而,目前对于TRPV1在鼻高反应性疾病中的研究尚缺乏系统性,因此,本文就TRPV1在鼻高反应性疾病中的作用进行综述,以期为鼻高反应性疾病的治疗提供理论依据和新的思路。

Nasal hyperreactive disease is a common upper airway disease in clinic.The pathogenesis of the disease with allergic rhinitis(AR)and vasomotor rhinitis(VMR)is complex.At present,the treatment strategy of the disease is mainly to improve the symptoms,but this disease can not be completely cured.Recent studies have found that transient receptor potential(TRP)ion channels may be the important targets for the treatment of nasal hyperreactive disease.Especially with the in-depth researches of transient receptor potential vanilloid 1(TRPV1),it is found that TRPV1 plays an important role in the neuro-immune regulatory network involved in the occurrence and development of nasal hyperreactive disease.By targeting TRPV1,a variety of drugs have shown promising therapeutic effects and clinical transformation prospect against nasal hyperreactive disease.At present,there is a lack of systematic research on TRPV1 in nasal hyperreactive disease.Therefore,this article reviews the role of TRPV1 in nasal hyperreactive disease,in order to provide theoretical basis and new ideas for the treatment of nasal hyperreactive disease.