花生四烯酸衍生物在腹主动脉瘤发生发展中的作用

The role of arachidonic acid derivatives in the development of abdominal aortic aneurysm

腹主动脉瘤(AAA)是老年群体常发疾病,发病率逐年上升,其容易破裂,死亡率高,目前并无有效药物可以延缓AAA的发生发展。AAA发病机制与细胞外基质降解、血管平滑肌细胞凋亡及炎症反应等密切相关。花生四烯酸衍生物广泛参与炎症反应、氧化应激等病理过程,尤其是前列腺素E2(PGE2)、前列腺素D2(PGD2)和血栓素A2(TXA2)等前列腺素,对AAA的发生发展具有重要作用。该文综述了花生四烯酸衍生物在AAA发生发展中的作用及其机制,以及药物的最新研究进展,为治疗AAA和发现新药物靶点提供思路。

Abdominal aortic aneurysm(AAA)is a common disease in the elderly,with an increasing incidence rate,easy rupture,high mortality,and no effective drugs to slow down the development of AAA.The pathogenesis of AAA is closely related to extracellular matrix degradation,apoptosis of vascular smooth muscle cells and inflammation.It has been found that arachidonic acid derivatives,especially prostaglandins such as prostaglandin E2(PGE2),prostaglandin D2(PGD2)and thromboxane A2(TXA2),play important roles in the development of AAA.Therefore,this review discusses the mechanism of arachidonic acid derivatives in the development of AAA,as well as the latest re-search progress of the drugs,to provide ideas for the treatment of AAA and the discovery of new drug targets.