茶多酚对氧化应激小鼠的抗氧化研究

Antioxidant effect of tea polyphenols on oxidative stress mice

氧化应激会造成脂质过氧化,诱导细胞凋亡且损伤细胞遗传物质,进而影响动物正常的生长发育过程。本文对喂饲茶多酚的小鼠进行氧化应激诱导,通过监测诱导后小鼠的体重和进食量,检测其血清和肝脏抗氧化指标,研究茶多酚对小鼠氧化应激的缓解效用。结果显示,氧化应激诱导前,各组小鼠的体重及进食量差异无统计学意义;氧化应激诱导后,应激组血清中的超氧化物歧化酶含量及总抗氧化水平显著下降,而茶多酚可以有效提高血清的抗氧化水平。同时,应激组小鼠肝脏过氧化氢酶及超氧化物歧化酶含量降低,丙二醛含量升高,而茶多酚处理可提高小鼠肝脏过氧化氢酶及超氧化物歧化酶含量,这表明茶多酚可以有效提高血清抗氧化水平,并保护小鼠肝脏,降低敌草快引起的氧化应激损伤。目的在于为进一步研究茶多酚缓解畜牧养殖中氧化应激提供参考。

Oxidative stress can cause lipid peroxidation,induce cell apoptosis,and damage cellular genetic material,thereby affecting the normal growth and development process of animals.This article induced oxidative stress in mice fed with tea polyphenols.By monitoring the weight and food intake of the induced mice,serum and liver antioxidant indicators were measured to study the alleviating effect of tea polyphenols on oxidative stress in mice.The results showed that before oxidative stress induction,there was no significant difference in weight and food intake among the groups of mice;after oxidative stress induction,the content of superoxide dismutase and total antioxidant in the serum of the stress group significantly decreased.Tea polyphenols could effectively increase the serum antioxidant level.At the same time,the content of catalase and superoxide dismutase in the liver of the stress group mice decreased,while the content of malondialdehyde increased.Tea polyphenol treatment could increase the content of catalase and superoxide dismutase in the liver of mice,this indicated that tea polyphenols could effectively increase serum antioxidant levels,protect mouse liver,and reduce oxidative stress damage caused by diquat.The purpose was to provide a reference basis for further research on how tea polyphenols alleviate oxidative stress in animal husbandry.