小胶质细胞在脓毒症相关性脑病中的作用及研究进展

The role and research progress of microglia in sepsis related encephalopathy

脓毒症相关性脑病(SAE)是脓毒症患者常见并发症,以脑功能障碍为主要特征,且相当比例的患者存在长期认知功能障碍。中枢神经系统是较早受到脓毒症引起的外周炎症影响的区域之一。小胶质细胞作为中枢神经系统常驻免疫细胞,可协调脑内炎症反应,在脑的固有免疫和适应性免疫应答中扮演重要角色,在SAE发生发展中起关键作用。就小胶质细胞功能表型及其在SAE中的作用进行综述以探讨小胶质细胞在SAE防治中的潜在价值。

Sepsis associated encephalopathy(SAE)is a common complication in patients with sepsis.It is characterized by brain dysfunction,and a considerable proportion of patients have long-term cognitive impairment.The central nervous system is one of earliest regions affected by peripheral inflammation caused by sepsis.As resident immune cells of central nervous system,microglia can coordinate inflammatory responses in brain and play an important role in the innate and adaptive immune responses of brain.Therefore,it plays a crucial role in the occurrence and development of SAE.In this paper,the functional phenotypes of microglia and their role in SAE are reviewed to explore the potential value of microglia in the prevention and treatment of SAE.