牛病毒性腹泻病毒疫苗研究进展

Advances on Vaccines of Bovine Viral Diarrhea Virus

牛病毒性腹泻病毒(BVDV)由BVDV-1、BVDV-2和BVDV-3三个亚种组成,是给养牛业造成巨大损失的重要病毒性病原体。接种BVDV疫苗是预防牛病毒性腹泻的主要策略之一。BVDV的结构蛋白E2和Erns是诱导中和抗体产生和激发保护性免疫应答的主要抗原蛋白,也是疫苗研究中常用的靶点蛋白。文章对BVDV的病原结构、宿主免疫应答以及目前BVDV经典疫苗和新型重组疫苗的最新研究进展进行了综述,以期为BVDV疫苗的研发领域提供参考。

The bovine viral diarrhea virus(BVDV)consists of 3 subspecies including BVDV-1,BVDV-2 and BVDV-3,and it is an important viral pathogen causing enormous losses to cattle industry.Vaccination is one of the main strategies for prophylaxis and contributes to the control and eradication of many viral diseases including BVDV.The structural proteins E2 and Erns of BVDV are the main antigenic proteins that induce production of neutralizing antibody and stimulate protective immune response,they are the also commonly used target proteins in BVDV vaccines research.In this review,we are focusing on the pathogenic structure of BVDV,the immune response of the host against the viral infection,and the recent advances of both classic vaccine and novel recombinant vaccine of BVDV,aiming at providing reference for the BVDV vaccine field.