PI3K/Akt信号通路在狼疮肾炎发病中的研究进展

Research progress of PI3K/Akt signaling pathway in the pathogenesis of lupus nephritis

狼疮肾炎(lupus nephritis,LN)是系统性红斑狼疮(systemic lupus erythematosus,SLE)中常见的并发症,其中10%~20%的LN患者会在确诊后5年内发展到终末期肾病,进而危及生命。磷脂酰肌醇3激酶(phosphatidylinositol 3 kinase,PI3K)/蛋白激酶B(protein kinase B,Akt)(简称PI3K/Akt信号通路)是细胞周期过程中重要的信号通路之一。近几年显示PI3K/Akt信号通路与LN的发生发展有关,文章总结了PI3K/Akt信号通路在LN中的机制研究和相关抑制剂,以期为LN的治疗靶点提供新的思路。

Lupus nephritis(LN)is a common complication of systemic lupus erythematosus(SLE),with 10%~20%of patients with LN developing the life-threatening end-stage renal disease within 5 years of diagnosis.Phosphatidylinositol 3 kinase(PI3K)/protein kinase B(Akt)(PI3K/Akt signaling pathway)is one of the important signaling pathways during the cell cycle.In recent years,it has been shown that PI3K/Akt signaling pathway is associated with the development of LN.The mechanistic studies of the PI3K/Akt signaling pathway in LN and related inhibitors,with a view to providing new ideas for therapeutic targets in LN were summarized.