CD137-CD137L与1型糖尿病的相关性研究进展

Research progress on the correlation between CD137-CD137L and type 1 diabetes

1型糖尿病(type 1 diabetes mellitus,T1DM)是一种多因素免疫介导的与自身免疫密切相关的疾病,其发病机制尚不完全明确,近年来发现,T细胞及其细胞亚群的活化与T1DM发生密切相关,而CD137-CD137L信号通路是T细胞活化的重要协调分子。文章就CD137-CD137L共刺激通路的相互作用及在T1DM发生、发展及免疫治疗中的影响进行综述。

Type 1 diabetes(T1DM)is a multifactorial immune mediated disease closely related to autoimmunity,and its pathogenesis is not completely clear.In recent years,it has been found that the activation of T cells and their subsets is closely related to the occurrence of T1DM,and CD137-CD137L signaling pathway is an important co modulator of T cell activation.The interaction of CD137-CD137L costimulatory pathway and its influence on the occurrence,development and immunotherapy in T1DM were reviewed.