巨噬细胞在肾纤维化发病机制和治疗中的研究进展

Research progress of macrophages in the pathogenesis and treatment of renal fibrosis

肾纤维化是肾脏组织受损后瘢痕修复的过程,是各种慢性肾脏病(chronic renal diseases,CKD)的最终结果。巨噬细胞参与炎症性肾脏疾病的发病过程并与CKD的纤维化进展密切相关。巨噬细胞表型和功能在整个病程中变化复杂,多种信号通路参与其中并介导纤维化的进程。文章概述了巨噬细胞表型和功能、在肾纤维化发病中的作用及靶向巨噬细胞对肾纤维化的治疗作用。

Renal fibrosis is the process of scar repair after renal tissue damage,and is the ultimate result of various chronic kidney diseases(CKD).Macrophages are involved in the pathogenesis of inflammatory kidney disease and closely related to the progression of CKD fibrosis.The phenotype and function of macrophages undergo complex changes throughout the entire disease process,with multiple signaling pathways involved and mediating the process of fibrosis.This review outlines the phenotype and function of macrophages,their role in the pathogenesis of renal fibrosis,and the therapeutic effect of targeted macrophages on renal fibrosis.