论穴位敏化过程与痒觉感受器激活相关性

Correlation between acupoint sensitization procedure and activation of pruriceptor

内脏病变通常以“牵涉性感觉异常”方式出现于体表特定部位,这些部位多与穴位相对应,而“按之快然”的穴位敏化属性及生物个体主动寻求按摩、抓挠的行为提示可能有“痒”的成分参与。新近发现的特异性痒觉感受器——表达Mas相关G蛋白偶联A3受体的神经元可能与穴位的“快然”特性相关,这类感受器在内脏病变时被激活,表现为诱发性痒觉敏化,促使我们渴望接受刺激以调控机能。痒觉感受器激活的动态过程与内脏牵涉性感觉异常所引发穴位“开合”属性的相关性研究,将为穴位敏化触发的自我刺激疗愈过程提供新的探索思路。

Visceral diseases usually accompany with hyperaesthesia phenomenon on the specific parts of the body surface.These parts are also the loci of sensitized acupoints.Meanwhile,in the acupoint sensitization attribute,pressing on acupoints make pleasure sensation and the behavior of individuals actively pursuing massage and scratching,which may be involved with itch sensation.The newly discovered peripheral itch receptor,dorsal root ganglion neurons which express Mas-generelated G protein-coupled receptors A3(Mrgpra3),may be related to the‘pleasure’characteristics of the acupoints.These types of receptors are activated during visceral lesions,manifested as inducible itching sensitization,which prompts us to crave stimulation to regulate function.Investigating the dynamic process of itch receptor activation and its correlation with the‘opening-closing’attributes of acupuncture points induced by referred hyperaesthesia will provide new avenues for exploring the self-stimulatory healing process triggered by acupoint sensitization.