基于肥大细胞与成纤维细胞的相互作用探讨手针针刺启动机制

Exploration on the initiation mechanism of manual acupuncture based on the mast cell-fibroblast interactions

针刺启动是针刺效应的决定环节。目前已知,穴区内的肥大细胞脱颗粒是将针刺力信号向神经电信号转化的关键步骤,同时也被认为是针刺启动必要的指标。但是针刺力究竟如何导致肥大细胞脱颗粒这一议题尚无定论。此外,穴区中数量最多的成纤维细胞在针刺启动过程中扮演的角色以及与肥大细胞之间的相互作用并不明朗。然而这些问题可能就是阐明针刺启动机制的关键环节。文章从机械信号在穴区的转化、肥大细胞的角色、肥大细胞对机械信号的反应、成纤维细胞可能扮演的角色以及成纤维细胞与肥大细胞之间在穴区可能发生的相互作用加以讨论,提供一个手针针刺启动研究未来的方向。

The effectiveness of acupuncture depends on the initiation of acupuncture at the acupoint.Currently,it has been accepted that the degranulation of mast cells is the key step for transformation of mechanical signals,generated by manual acupuncture,to neurotransmitters which trigger neuron transmission.This step is also recognized as the necessary index of successful initiation of acupuncture.However,it is still unclear how manual acupuncture can cause the degranulation of mast cells.Meanwhile,the role of fibroblasts,the most abundant cells inside the acupoint,and their relationship with mast cells are not well understood.However,the explanation of these questions might be the critical parts to disclosure the mechanisms of acupuncture initiation.This article therefore discusses the following points:the transformation of mechanical signals in the acupoint;the role of mast cells in acupuncture initiation;the response of mast cells to mechanical signals;the possible role of fibroblasts in acupuncture initiation;and the possible interaction between fibroblasts and mast cells in the acupoint.This article aims to provide a future direction for the study of manual acupuncture initiation.