臭氧联合低温等离子射频热凝术治疗椎间盘源性腰痛的效果及对患者炎症因子水平的影响

Efficacy of ozone combined with low-temperature plasma radiofrequency thermocoagulation on discogenic lumbodynia and its impact on patients′ inflammatory factor levels

目的探讨臭氧联合低温等离子射频热凝术治疗椎间盘源性腰痛的效果及对患者炎症因子水平的影响。方法选取2022年5月至2023年5月在首都医科大学附属北京安贞医院疼痛科治疗的腰椎间盘突出患者104例,按随机数字表法分成对照组和观察组,每组52例。对照组行低温等离子射频热凝术治疗,观察组行臭氧联合低温等离子射频热凝术治疗。比较2组临床疗效,疼痛视觉模拟量表(VAS)评分、Oswestry功能障碍指数问卷表(ODI)评分,治疗前及治疗后2周白细胞介素1β(IL-1β)、IL-6、IL-8和肿瘤坏死因子α(TNF-α)水平,以及治疗后不良反应发生情况。结果观察组优良率高于对照组[94.2%(49/52)比78.8%(41/52)],差异有统计学意义(P<0.001)。治疗后2周,2组的VAS及ODI评分均低于治疗前且观察组均低于对照组[组间:(1.4±1.2)分比(2.4±1.0)分、(13±4)分比(23±5)分],差异均有统计学意义(均P<0.001)。治疗后2周,2组血浆IL-1β、IL-6、IL-8和TNF-α水平均低于治疗前且观察组均低于对照组,差异均有统计学意义(均P<0.001)。2组不良反应发生率差异无统计学意义(P=1.000)。结论臭氧联合低温等离子射频热凝术是治疗椎间盘源性腰痛的一种安全、有效的方法,可明显降低炎症因子水平。

Objective To investigate the efficacy of ozone combined with low-temperature plasma radiofrequency thermocoagulation on discogenic lumbodynia and its impact on patients′inflammatory factor levels.Methods A total of 104 patients with discogenic lumbodynia who were treated in the Department of Pain Management,Beijing Anzhen Hospital,Capital Medical University from May 2022 to May 2023 were selected.According to the random number table method,they were divided into control group and observation group,with 52 cases in each group.The control group was treated with low-temperature plasma radiofrequency thermocoagulation,and the observation group was treated with ozone combined with low-temperature plasma radiofrequency thermocoagulation.Clinical efficacy,pain visual analogue scale(VAS)score,Oswestry dysfunction index questionnaire(ODI)score,levels of interleukin-1β(IL-1β),IL-6,IL-8 and tumor necrosis factor-α(TNF-α)before and after treatment,and incidence of adverse reactions after treatment were compared.Results The excellent rate of the observation group was higher than that of the control group[94.2%(49/52)vs 78.8%(41/52)](P<0.001).After 2 weeks of treatment,the VAS and ODI scores of the two groups were lower than those before treatment,and those of the observation group were lower than those of the control group[between two groups:(1.4±1.2)vs(2.4±1.0),(13±4)vs(23±5)](both P<0.001).After 2 weeks of treatment,the levels of serum IL-1β,IL-6,IL-8 and TNF-αin both groups were lower than those before treatment,and those in the observation group were lower than those in the control group(all P<0.001).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P=1.000).Conclusion Ozone combined with low-temperature plasma radiofrequency thermocoagulation is a safe and effective method for the treatment of discogenic lumbodynia,which can significantly reduce the levels of inflammatory factors.