4+7集中采购药品政策对我院临床抗菌药物使用情况的影响

Influence of 4+7 centralized procurement policy on the use of clinical antibiotics in our hospital

目的探究4+7集中采购药品政策(简称集采政策)对我院临床抗菌药物使用情况的影响。方法应用医院信息系统,收集并分析抗菌药物的品种数量、销售金额、用药频度(DDDs)及日均费用(DDC),对比我院2018年1月至2019年11月(集采政策实施前)与2019年12月至2022年12月(集采政策实施后)的临床抗菌药物使用情况。结果本院内使用抗菌药物包括头孢呋辛酯片、阿奇霉素片等;集采政策实施后的抗菌药物数量较集采政策实施前增长2.46%,抗菌药物品种数量前三位分别为头孢呋辛酯片、左氧氟沙星片及环丙沙星片,其中头孢呋辛酯片数量增加最为显著,较集采政策实施前增幅达36.32%。集采政策实施后的抗菌药销售金额同集采政策实施前下降,降幅达84.68%;左氧氟沙星片销售金额降低比例最大,降幅达93.46%。集采政策实施后,抗菌药物中DDDs值排名前三的药物分别为阿奇霉素片、左氧氟沙星片及头孢呋辛酯片。集采政策实施后,抗菌药物中DDC值排名前三的药物分别为左氧氟沙星氯化钠注射液、注射用阿奇霉素及环丙沙星片。结论4+7集采政策有效降低了部分临床抗菌药物的销售金额,增加了使用频率,临床应重视抗菌药物合理使用,警惕药物滥用。

Objective To explore the influence of 4+7 centralized procurement policy(referred to as the collection policy)on the use of clinical antibiotics in our hospital.Methods The hospital information system was used to collect and analyze the number of varieties,sales amount,defined daily dose system(DDDs)and defined daily cost(DDC)of antibiotics,and to compare the clinical use of antibiotics in our hospital from January 2018 to November 2019(before the implementation of the collection policy)and from December 2019 to December 2022(after the implementation of the collection policy).Results The antibiotics used in the hospital included cefuroxime axetil tablets,azithromycin tablets,etc;after the implementation of the collection policy,the number of antibacterial drugs increased by 2.46%,the top three varieties of antibacterial drugs were cefuroxime axetil tablets,levofloxacin tablets and ciprofloxacin tablets,among them,the number of cefuroxime axetil tablets increased the most significantly,with an increase of 36.32%compared with that before the implementation of the collection policy.After the implementation of the collection policy,the sales amount of antibacterial drugs decreased by 84.68%compared with that before the implementation of the collection policy;the sales amount of levofloxacin tablets decreased the most,with a decrease of 93.46%.After the implementation of the collection policy,the top three drugs in DDDs values of antibiotics were azithromycin tablets,levofloxacin tablets and cefuroxime axetil tablets.After the implementation of the collection policy,the top three drugs in DDC values of antibiotics were levofloxacin sodium chloride injection,azithromycin for injection and ciprofloxacin tablets.Conclusion The 4+7 collection policy has effectively reduced the sales amount of some clinical antibiotics and increased the frequency of use.Clinical attention should be paid to the rational use of antibiotics and drug abuse.