肺力咳联合盐酸氨溴特罗对支原体肺炎患儿症状改善及肺功能的影响

Effects of Feilike combined with ambroxol hydrochloride on symptoms improvement and lung function in children with mycoplasma pneumonia

目的探讨肺力咳联合盐酸氨溴特罗对支原体肺炎患儿症状改善及肺功能的影响。方法选取2021年3月至2023年3月收治的89例支原体肺炎患儿为研究对象,将其随机分为对照组(44例,盐酸氨溴特罗治疗)及研究组(45例,肺力咳联合盐酸氨溴特罗治疗)。比较两组的治疗效果。结果研究组的止咳时间、咳痰改善时间、退热时间及肺啰音消失时间明显短于对照组(P<0.05)。研究组的治疗总有效率明显高于对照组(P<0.05)。治疗后,研究组的呼气峰值流速(PEF)、用力肺活量(FVC)及最大呼气中段流量(MMF)明显高于对照组(P<0.05)。治疗后,研究组的C-反应蛋白(CRP)、降钙素原(PCT)水平明显低于对照组(P<0.05)。治疗后,研究组的CD4^(+)、CD4^(+)/CD8^(+)明显高于对照组,CD8^(+)低于对照组(P<0.05)。两组的并发症总发生率无明显差异(P>0.05)。结论肺力咳联合盐酸氨溴特罗可改善支原体肺炎患儿的临床症状,提高治疗效果、肺功能及免疫功能,降低炎症因子水平。

Objective To investigate the effects of Feilike combined with ambroxol hydrochloride on symptoms improvement and lung function in children with mycoplasma pneumonia.Methods A total of 89 children with mycoplasma pneumonia admitted from March 2021 to March 2023 were selected as the research objects and randomly divided into control group(44 cases,treated with ambroxol hydrochloride)and study group(45 cases,treated with Feilike combined with ambroxol hydrochloride).The therapeutic effects of the two groups were compared.Results The cough relieving time,sputum improvement time,antipyretic time and lung rale disappearance time in the study group were significantly shorter than those in the control group(P<0.05).The total effective rate of treatment in the study group was significantly higher than that in the control group(P<0.05).After treatment,the peak expiratory flow(PEF),forced vital capacity(FVC)and maximal mid-expiratory flow curve(MMF)in the study group were significantly higher than those in the control group(P<0.05).After treatment,the levels of C-reactive protein(CRP)and procalcitonin(PCT)in the study group were significantly lower than those in the control group(P<0.05).After treatment,the CD4^(+)and CD4^(+)/CD8^(+)in the study group were significantly higher than those in the control group,and the CD8^(+)was lower than that in the control group(P<0.05).There was no significant difference in the total incidence of complications between the two groups(P>0.05).Conclusion Feilike combined with ambroxol hydrochloride can improve the clinical symptoms of children with mycoplasma pneumonia,improve the therapeutic effect,lung function and immune function,and reduce the levels of inflammatory factors.