柴胡疏肝散加味辅助雷贝拉唑对慢性萎缩性胃炎患者中医证候积分及胃肠功能的影响

Effect of Chaihu Shugan Powder supplemented with Rabeprazole on TCM syndrome score and gastrointestinal function in patients with chronic atrophic gastritis

目的:探讨柴胡疏肝散加味辅助雷贝拉唑治疗慢性萎缩性胃炎(Chronic atrophic gastritis,CAG)的疗效。方法:选取我院2019年5月—2022年5月收治的CAG患者80例,依随机数表法分为研究组(40例)和对照组(40例)。对照组行雷贝拉唑治疗,研究组行柴胡疏肝散加味辅助雷贝拉唑治疗。治疗2个月后,比较两组疗效、中医证候积分、胃黏膜病理变化评分、胃肠功能指标[胃蛋白酶原Ⅰ(PGⅠ)、表皮生长因子(EGF)、胃泌素(GAS)、胃蛋白酶原Ⅱ(PGⅡ)]、不良反应发生率。结果:治疗2个月后研究组总有效率(95.00%,38/40)高于对照组(80.00%,32/40)(P<0.05);治疗2个月后研究组中医证候积分改善程度优于对照组(P<0.05);治疗2个月后研究组胃黏膜病理变化评分低于对照组(P<0.05);治疗2个月后研究组GAS水平低于对照组,EGF、PGⅠ、PGⅡ水平高于对照组(P<0.05);治疗期间研究组不良反应总发生率(12.50%,5/40)与对照组(7.50%,3/40)相比,差异无统计学意义(P>0.05)。结论:柴胡疏肝散加味辅助雷贝拉唑治疗CAG可进一步提升疗效,改善患者中医证候积分,促进肠胃功能恢复,利于病情转归。

Objective: To investigate the curative effect of Chaihu Shugan Powder supplemented with Rabeprazole in the treatment of Chronic atrophic gastritis(CAG). Methods: A total of 80 CAG patients admitted to our hospital from May 2019 to May 2022 were selected and divided into study group(40 cases) and control group(40 cases) according to random number table method. The control group was treated with rabeprazole, and the study group was treated with Buplehu Shugan powder supplemented with rabeprazole. After 2 months of treatment, the efficacy, TCM syndrome score, gastric mucosal pathological change score, gastrointestinal function index [pepsinogen Ⅰ(PG-ⅰ), epidermal growth factor(EGF), gastrin(GAS),pepsinogen Ⅱ(PG-ⅱ)] and incidence of adverse reactions were compared between the two groups. Results: After 2 months of treatment, the total effective rate of the study group(95.00%, 38/40) was higher than that of the control group(80.00%,32/40)(P < 0.05). After 2 months of treatment, the improvement of TCM syndrome scores in the study group was better than that in the control group(P < 0.05). After 2 months of treatment, the score of gastric mucosal pathological changes in the study group was lower than that in the control group(P < 0.05). After 2 months of treatment, the GAS level of the study group was lower than that of the control group, and the EGF, PG-ⅰ and PG-ⅱ levels were higher than those of the control group(P < 0.05). There was no significant difference in the total incidence of adverse reactions between the study group(12.50%, 5/40) and the control group(7.50%, 3/40) during treatment(P > 0.05). Conclusion: Chaihu Shugan Powder supplemented with Rabeprazole in the treatment of CAG can further improve the curative effect, improve the TCM syndrome score of patients, promote the recovery of gastrointestinal function, and facilitate the outcome of the disease.