复荣通脉胶囊对ACS-PCI患者红细胞分布宽度和血小板与淋巴细胞比值的影响

Influences of Furong Tongmai Capsule(复荣通脉胶囊)on Red Blood Cell Distribution Width and Platelet to Lymphocyte Ratio in ACS-PCI Patients

目的评价复荣通脉胶囊对急性冠状动脉综合征(ACS)患者经皮冠状动脉介入治疗(PCI)术后红细胞分布宽度(RDW)和血小板与淋巴细胞比值(PLR)的影响。方法选取2019年6月—2021年6月河北省沧州中西医结合医院确诊ACS并进行PCI术的168例患者为研究对象,均口服复荣通脉胶囊至少3个月,中位时间8.5个月。所有患者PCI术后常规随访12个月,根据是否有短期主要心脏不良事件(major adverse cardiac events,MACE)分为MACE组24例与无MACE组144例,比较两组术后和随访12个月时的RDW和PLR值。分析MACE与RDW、PLR的相关性,并分析RDW、PLR对ACS-PCI术后MACE发生的预测价值。结果MACE组复荣通脉胶囊服用时间明显短于无MACE组(P<0.05),两组术后RDW和PLR比较,差异无统计学意义(P>0.05),但MACE组随访12个月时RDW比无MACE组明显升高(P<0.05),而PLR则明显下降(P<0.05)。Logistic回归分析显示,复荣通脉胶囊服用时间、RDW和PLR均是ACS-PCI患者随访12个月时MACE发生的预测因素(P<0.05)。受试者工作曲线(ROC)显示,RDW和PLR预测ACS-PCI术后MACE发生的曲线下面积(AUC)分别为0.854和0.897(P<0.05)。结论复荣通脉胶囊及其服用时间长短对ACS-PCI术后MACE发生具有重要影响,复荣通脉胶囊服用时间、RDW和PLR均是ACS-PCI术后MACE发生的预测因素,长期服用复荣通脉胶囊可降低RDW值,升高PLR值,进而降低ACS-PCI术后MACE的发生率。

Objective To evaluate the effect of Furong Tongmai Capsule(复荣通脉胶囊)on red blood cell distribution width(RDW)and platelet to lymphocyte ratio(PLR)in patients with acute coronary syndrome(ACS)after percutaneous coronary intervention(PCI).Methods From June 2019 to June 2021,168 patients with ACS into our hospital after PCI were selected,all of them took Furong Tongmai Capsule for at least 3 months,with a median time of 8.5 months.The patients were followed up for 12 months and divided into major adverse cardiac events(MACE)group(n=24)and non-MACE group(n=144).RDW and PLR values of the two groups were compared after surgery and 12 months of follow-up.The correlation between MACE,RDW and PLR was analyzed,and the predictive value of RDW and PLR for the occurrence of MACE after ACS-PCI was analyzed.Results The time of taking Furong Tongmai Capsule in MACE group was shorter than non-MACE group(P<0.05).There was no difference of RDW and PLR after PCI between the two groups(P>0.05),but RDW after 12 months of follow-up in MACE group was higher than non-MACE group,while PLR was lower(P<0.05).Logistic regression showed that the taking time of Furong Tongmai Capsule,RDW and PLR were predictive factors of MACE in ACS-PCI patients after 12 months follow-up(P<0.05).The area under curve(AUC)of RDW and PLR for predicting MACE by receiver operating curve(ROC)were 0.854 and 0.897 respectively(P<0.05).Conclusion Furong Tongmai Capsule and its duration of administration have an important effect on the occurrence of MACE after ACS-PCI.Taking time of Furong Tongmai Capsule,RDW and PLR were all predictive factors of MACE after ACS-PCI.Long-term administration of Furong Tongmai Capsule can decrease RDW value and increase PLR value,thus reducing the incidence of MACE after ACS-PCI.