复荣通脉胶囊联合中药足浴治疗糖尿病高危足疗效及对血清NGF、IL-1β水平的影响

Curative Effect of Furong Tongmai Capsule(复荣通脉胶囊)Combined with Herbal Foot Bath on High-risk Diabetic Feet and Its Influences on Levels of Serum NGF and IL-1β

目的探究复荣通脉胶囊联合中药足浴治疗糖尿病高危足疗效及对血清神经生长因子(NGF)、白细胞介素-1β(IL-1β)水平的影响。方法选取2021年5月—2022年8月门诊就诊筛选的120例糖尿病高危足人群为研究对象,随机分为治疗组和对照组各60例,对照组给予中药足浴治疗,观察组在此基础上给予复荣通脉胶囊治疗,持续治疗12周,观察两组临床疗效、中医证候积分、踝肱指数(ABI)与多伦多临床评分系统(TCSS)评分、足背动脉血流参数、血液流变学状态、神经传导速度以及血清NGF、IL-1β水平。结果观察组总有效率(96.67%)高于对照组(85.00%)(P<0.05);观察组心悸气短、疲乏无力、头晕耳鸣、肢体麻木各项积分均低于对照组(P<0.05);观察组治疗后ABI值高于对照组,TCSS评分低于对照组(P<0.05);观察组治疗后足背动脉内径、收缩期峰值流速(Vs)高于对照组,阻力指数(RI)低于对照组(P<0.05);观察组治疗后全血低切与高切黏度、纤维蛋白原、血浆黏度值低于对照组(P<0.05);观察组胫神经及腓总神经传导速度均高于对照组(P<0.05);观察组治疗后血清NGF水平明显高于对照组,IL-1β水平低于对照组(P<0.05)。结论复荣通脉胶囊联合中药足浴可明显降低糖尿病高危足患者中医证候积分,改善足背动脉血流参数,降低血液黏度,提升神经传导速度,改善神经功能。

Objective To explore the curative effect of Furong Tongmai Capsule(复荣通脉胶囊)combined with herbal foot bath on high-risk diabetic feet and its influences on levels of serum nerve growth factor(NGF)and interleukin-1β(IL-1β).Methods A total of 120 patients with high-risk diabetic feet treated in outpatient department were enrolled as the research objects between May 2021 and August 2022,and they were randomly divided into treatment group(n=60)and control group(n=60).The control group was treated with herbal foot bath,while treatment group was additionally treated with Furong Tongmai Capsules for 12 weeks.The clinical curative effect,scores of TCM syndromes,ankle-brachial index(ABI),score of Toronto Clinical Scoring System(TCSS),blood flow parameters of dorsalis pedis artery,hemorheology status,nerve conduction velocity,levels of serum NGF and IL-1βin the two groups were observed.Results The total response rate of observation group was higher than that of control group(96.67%vs 85.00%,P<0.05).After treatment,scores of TCM syndromes(palpitation and shortness of breath,fatigue,dizziness and tinnitus,limb numbness)in observation group were lower than those in control group(P<0.05).After treatment,ABI in observation group was greater than that in control group,while TCSS score was lower than that in control group(P<0.05).After treatment,diameter of dorsalis pedis artery and peak systolic velocity(Vs)in observation group were higher than those in control group,while resistance index(RI)was lower than that in control group(P<0.05).After treatment,whole blood low-shear and high-shear viscosity,fibrinogen and plasma viscosity in observation group were lower than those in control group(P<0.05).The conduction velocity of tibial nerve and common peroneal nerve in observation group was faster than that in control group(P<0.05).After treatment,level of serum NGF in observation group was significantly higher than that in control group,while IL-1βlevel was lower than that in control group(P<0.05).Conclusion Furong Tongmai Capsule combined with herbal foot bath can significantly reduce scores of TCM syndromes,improve blood flow parameters of dorsalis pedis artery,reduce blood viscosity,accelerate nerve conduction and improve nerve function in patients with high-risk diabetic feet.