人间充质干细胞在生殖医学领域中的基础研究进展

Basic research progress of human mesenchymal stem cells in the field of reproductive medicine

生殖医学的快速发展为助力解决人口问题作出了突出贡献,但仍无法满足所有的夫妇成为遗传学层面的"完整父母"。随着再生医学研究的深入,研究者发现干细胞具有促进内源性修复、改善氧化应激水平、调节免疫微环境等特性。因此,干细胞移植被认为是恢复受损生殖功能的有效疗法。由于来源广泛、容易获得和低免疫原性的特点,间充质干细胞被认为是移植治疗的理想来源,并且在大量生殖领域的科学和临床研究中被证明是有效的。本文就国内外各类间充质干细胞在生殖医学领域中的基础研究进展进行综述。

The rapid development of reproductive medicine has made outstanding contribution to the solution of population problem,but it still cannot satisfy all couples to become"complete parents"at the genetic level.As research progressed of regenerative medicine,it is found that the stem cells have the characteristics of promoting endogenous repair,improving oxidative stress level,regulating immune microenvironment,and so on.Therefore,the transplantation of stem cells is considered to be a new and effective therapy to restore the damaged reproductive function.The mesenchymal stem cells are considered as an ideal source for transplantation therapy because of the characteristics of wide source,easy acquisition and low immunogenicity.Furthermore,it has been proven effective in a large number of scientific and clinical researches in the reproductive field.This paper reviews the basic research progress on all kinds of mesenchymal stem cells in the field of reproductive medicine at home and abroad.