DNA甲基化检测在肿瘤诊疗中的应用

The application of methylation detection in tumor diagnosis and treatment

肿瘤靶基因甲基化检测技术在癌症早期筛查、治疗药物选择、疗效监测、预后预测等方面具有良好的应用前景和发展空间。大量研究表明,检测单个癌症靶基因甲基化水平在肿瘤早期诊断和治疗策略选择中具有巨大潜力。以肺癌、肝癌、鼻咽癌、妇科生殖道肿瘤的子宫颈癌与子宫内膜癌等DNA甲基化检测为切入点,可从癌靶基因筛选、基因甲基化的生物学和临床意义探索DNA甲基化临床转化可行性与价值。未来开展更多前瞻性大样本量临床研究,有望将其转化为临床诊断和治疗的重要生物标志物。

Cancer-specific target gene methylation detection technology has shown good application prospects and development in early cancer screening,selection of therapeutic drugs,efficacy monitoring,and prediction of prognosis.Taking the diagnosis and treatment of cancer including lung cancer,liver cancer and ovarian cancer,etc.as the entry point of cancer-specific target gene methylation clinical research,highlighting the clinical significance of methylation biomarkers in early screening,differential diagnosis,and prediction of recurrence of tumors.Research on the biological significance and clinical approaches of cancer-specific targeted gene methylation in tumors,as well as conducting prospective large-scale clinical studies,holds great promise to transform it into important biomarkers for clinical diagnosis and treatment in the future.