产酸克雷伯菌致病性及相关毒力因子研究进展

Research progress on pathogenicity and related virulence factors of Klebsiella oxytoca

产酸克雷伯菌是一种重要条件致病菌,可引起成人、儿童、社区或医院获得性感染。其中,产酸克雷伯菌最常引起的疾病是抗生素相关出血性结肠炎(AAHC)。此外,它还可引起尿路感染、肺部感染、血流感染等疾病。目前,关于产酸克雷伯菌致病相关的机制研究较少,其中较为明确的有产细胞毒素Tilivalline和Tilimycin,作为产酸克雷伯菌重要的毒力因子,可导致AAHC的发生。考虑到国内关于产酸克雷伯菌的研究较少,本文就产酸克雷伯菌的流行率、致病性及其相关机制进行了综述,希望能提高大家对产酸克雷伯菌的认识,并为疾病预防和治疗提供指导。

Klebsiella oxytoca is an important opportunistic pathogen which cause community or hospital-acquired infections in adults and children.The disease it most causes is antibiotic-associated hemorrhagic colitis(AAHC).It can also cause diseases such as urinary tract infections,pneumonia and bloodstream infections.The cytotoxins including Tilivalline and Tilimycin are important virulence factors for Klebsiella oxytoca,mainly causing AAHC.This article reviewed the progress of research on the prevalence,pathogenicity and mechanisms of K.oxytoca,hoping to improve the understanding of K.oxytoca and provide guidance on disease prevention and treatment.