当归化学成分及药理作用研究进展

Research Progress on Chemical Components and Pharmacological Effects of Danggui(Angelicae Sinensis Radix)

当归在补血药中因“补而不滞”的特点,被广泛用于临床。其化学成分主要包括挥发油类、多糖类、有机酸类、氨基酸类、黄酮类等,常用水蒸气蒸馏法、超临界CO_(2)萃取法、有机溶剂萃取法、煎煮法、渗漉法、超声提取等方法进行提取,而炮制方式、地域、物候期、药用部位的不同皆可影响其化学成分。关于当归药理作用的研究亦愈发深入,当前已证实的包括调节血液循环、缺血后损伤保护、抗组织纤维化、镇痛、保护脑和神经、改善机体骨损伤状态、提高机体免疫力等。参考文献76篇。

Danggui(Angelicae Sinensis Radix)is widely used in clinical practice because of the characteristics of“tonifying without stagnation”in blood tonics.Its chemical composition mainly includes volatile oils,polysaccharides,organic acids,amino acids,flavonoids,etc.,which are commonly extracted by steam distillation,supercritical CO_(2) extraction,organic solvent extraction,decoction,osmosis,ultrasonic extraction and other methods,and the chemical composition can be affected by the difference in processing methods,regions,phenological periods,and medicinal parts.The pharmacological effects of Danggui have also become more and more in-depth,and the current confirmed ones include regulating blood circulation,post-ischemic injury pro⁃tection,anti-tissue fibrosis,analgesia,protecting the brain and nerves,improving the body’s bone injury state,and improving the body’s immunity.There are 76 references.