宽胸气雾剂对心绞痛患者微循环功能障碍的影响及其临床疗效研究

A study of effects and clinical efficacy of“Broad Chest”aerosol on microcirculation dysfunction in patients with angina pectoris

目的探讨宽胸气雾剂对心绞痛患者微循环障碍的影响及其临床疗效。方法本项目是一项前瞻性随机对照研究,入组冠脉造影检测caIMR微循环阻力指数(IMR)≥25诊断为微血管性心绞痛的患者100例。将100例患者随机分为宽胸气雾剂+西药治疗组(观察组,50例)与单用西药治疗组(对照组,50例)。通过检测观察组患者使用宽胸气雾剂前后IMR数值,分析冠脉微循环受到的阻力情况。比较2组3个月随访期间运动心肺功能情况,以及中医证候积分及加拿大心绞痛评分情况。结果2组的一般临床情况无统计学意义(P>0.05)。宽胸气雾剂能够显著改善患者的冠脉微循环阻力,随访3个月后,宽胸气雾剂组能够显著改善患者的运动心肺试验METS水平(P<0.05)。在随访3个月期间,宽胸气雾剂组能够显著改善患者中医症候积分及加拿大心绞痛评分,具有统计学意义(P<0.05)。结论宽胸气雾剂能够改善微血管性心绞痛的冠脉微循环阻力,能够有效缓解心绞痛症状,在临床上有一定的应用价值。

Objective To explore the effects of“Broad Chest”aerosol on microcirculation dysfunction in patients with angina pectoris and its clinical efficacy.Methods This is a prospective randomized controlled study.A total of 100 patients with microvascular angina pectoris diagnosed by coronary angiography with a caIMR microcirculation resistance index(IMR)≥25 were enrolled.They were randomly divided into observation group(50 cases,treated with“Broad Chest”aerosol plus Western medicine)and control group(50 cases,treated with Western medicine alone).The IMR values of patients in the observation group before and after using“Broad Chest”aerosol were detected to analyze the resistance of coronary microcirculation.The cardiopulmonary function,traditional Chinese medicine(TCM)syndrome score and Canadian angina pectoris score were compared between the two groups during 3-month follow-up.Results The general clinical conditions of the two groups were not statistically significant(P>0.05).“Broad Chest”aerosol can significantly improve coronary microcirculation resistance of patients.After 3 months of follow-up,the METS level of exercise cardiopulmonary test of the observation group significantly improved(P<0.05).During the follow-up period of 3 months,the TCM symptom scores and Canadian angina pectoris scores of the observation group were significantly improved,with statistical significance(P<0.05).Conclusion“Broad Chest”aerosol can improve coronary microcirculation resistance in patients with microvascular angina,effectively alleviate angina symptoms,and has certain clinical application value.