空腹血糖和血脂指标联合检测在糖尿病患者生化检验中的应用

Application of combined detection of fasting blood glucose and blood lipid indexes in biochemical examination of patients with diabetes mellitus

目的探讨空腹血糖(FBG)和血脂指标联合检测在糖尿病患者生化检验中的应用。方法选择2020年7月—2022年7月在聊城市第二人民医院就诊的1000例糖尿病患者作为研究对象,纳入观察组;将同期1000例健康体检者作为对照组。两组受检者均进行生化检验,采用己糖激酶法测定FBG,采用氧化酶法测定总胆固醇(TC)、三酰甘油(TG),采用直接检测法测定高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。比较两组上述指标的检测结果;计算并比较各指标单独与联合检测的阳性率;应用Pearson系数分析FBG与血脂指标的相关性。结果观察组的FBG、TC、TG、LDL-C水平均明显高于对照组,HDL-C水平明显低于对照组[FBG(mmol/L):8.56±1.28比5.06±0.33;TC(mmol/L):6.31±0.72比4.20±0.47;TG(mmol/L):2.80±0.51比0.84±0.20;LDL-C(mmol/L):3.97±0.48比1.07±0.29;HDL-C(mmol/L):0.78±0.13比1.40±0.30;均P<0.05]。观察组的FBG和血脂指标单独与联合检测的阳性检出率均明显高于对照组(FBG:89.70%比2.50%;血脂指标:75.90%比10.60%;联合检测:98.60%比0.70%;均P<0.05),且观察组联合检测的阳性检出率明显高于FBG和血脂指标检测(98.60%比89.70%、75.90%,均P<0.05)。观察组的FBG与TC、TG、LDL-C均呈负相关(r值分别为-0.586、-0.411、-0.429,P值均为0.001),与HDL-C呈正相关(r值为0.947,P值为0.001)。结论FBG与血脂指标联合检测可促进糖尿病诊断准确率的提升。

Objective To investigate the application of combined detection of fasting blood glucose(FBG)and blood lipid indexes in biochemical test of patients with diabetes mellitus.Methods The 1000 patients with diabetes mellitus who were treated in the Second People's Hospital Liaocheng from July 2020 to July 2022 were selected as research objects and included in observation group,and 1000 healthy physical examiners during the same period were included in control group.Biochemical tests were performed in two groups.The level of FBG was determined by hexokinase method,the levels of total cholesterol(TC)and triglyceride(TG)were determined by oxidase method,and the levels of high-density lipoprotein cholesterol(HDL-C)and lowdensity lipoprotein cholesterol(LDL-C)were determined using direct detection method.The detection results of the above indicators between two groups were compared,the positive rates of individual and combined detection for each indicator were calculated and compared,and the correlation between FBG and blood lipid indicators was analyzed using Pearson coefficient analysis.Results The levels of FBG,TC,TG and LDL-C in observation group were significantly higher than those in control group,while the level of HDL-C was significantly lower than that in control group[FBG(mmol/L):8.56±1.28 vs.5.06±0.33,TC(mmol/L):6.31±0.72 vs.4.20±0.47,TG(mmol/L):2.80±0.51 vs.0.84±0.20,LDL-C(mmol/L):3.97±0.48 vs.1.07±0.29,HDL-C(mmol/L):0.78±0.13 vs.1.40±0.30,all P<0.05].The positive rates of FBG,blood lipid indexes and combined detection in observation group were significantly higher than those in control group(FBG:89.70%vs.2.50%;blood lipid indexes:75.90%vs.10.60%;combined detection:98.60%vs.0.70%;all P<0.05),and the positive rate of combined detection in observation group was significantly higher than those of single detection of FBG and blood lipid indexes(98.60%vs.89.70%,75.90%,both P<0.05).The level of FBG in observation group was negatively correlated with the levels of TC,TG and LDL-C(r values were-0.586,-0.411 and-0.429,P values were all 0.001),and the level of FBG was positively correlated with HDL-C(r value was 0.947,P value was 0.001).Conclusions The combined detection of FBG and blood lipid indexes could improve the diagnostic accuracy of diabetes mellitus.