基于代谢组学探讨中医肾虚证物质基础研究概况

Discussion on Research Overview of Material Basis of TCM Kidney Deficiency Syndrome Based on Metabonomics

“证候”是中医学辨证论治的理论基石,证候的表型组学研究是回答中医药科学性问题的关键环节。肾虚证在临床各科疾病中极为常见,但其客观化研究仍存在物质基础认识模糊、评价标准不完备等难点。代谢组学符合中医学“整体观念”特征,为揭示证候理论实质提供新视角,可较好地结合系统生物学与中医证候。本文梳理肾虚致病的复杂性、多样性与机体代谢网络失稳的相关性,认为氨基酸代谢、菌群代谢及能量代谢紊乱等是中医肾虚证的微观物质体现,且不同疾病的同一证型、同一证型不同表型间的内源性代谢产物均具备良好鉴别效应与诊断价值,可为进一步阐释中医证候学特征、肾虚证实质认识及客观评价研究提供参考。

“Syndrome”is the theoretical cornerstone of TCM syndrome differentiation and treatment,and the phenomic study of syndrome is the key link to answer the scientific questions of TCM.Kidney deficiency syndrome is very common in clinical diseases,but its objectification research still has some difficulties,such as confusing understanding of material basis and incomplete evaluation criteria.Metabolomics conforms to the“holistic concept”of TCM and can provide a new perspective to reveal the essence of syndrome theory.It is considered to be the hub and bridge between systems biology and TCM syndrome.This article reviewed the correlation between the complexity and diversity of kidney deficiency syndrome and the instability of the body’s metabolic network.It is believed that amino acid metabolism,microbial metabolism,and energy metabolism disorders are the micro material manifestations of TCM kidney deficiency syndrome.Moreover,the endogenous metabolites of the same syndrome type of different diseases and different phenotypes of the same syndrome have good differential effects and diagnostic value,which can provide reference for further elucidating the characteristics of TCM syndromes,understanding the essence of kidney deficiency syndrome,and objectively evaluating research.