丹红注射液联合倍他司汀治疗急性眩晕患者的效果

Effect of Danhong injection combined with betahistine in the treatment of patients with acute vertigo

目的:探究丹红注射液联合倍他司汀对急性眩晕患者脑血流动力学及凝血指标的影响。方法:于2021年2月—2023年2月选取本院诊治的急性眩晕患者60例为研究对象,以随机数字法将其分为观察组30例与对照组30例。两组入选患者均实施降压、降糖等常规治疗;对照组静脉注射45 min倍他司汀20 mg+氯化钠注射液250 ml;观察组在对照组用药基础上静脉注射45 min丹红注射液30 ml+氯化钠注射液250 ml。评价比较两组临床疗效,并比较两组治疗前后眩晕程度、脑血流动力学指标及凝血指标。结果:治疗1周后,观察组的总有效率为93.33%(28/30),对照组为73.33%(22/40),观察组显著高于对照组(P<0.05)。治疗前,两组患者的眩晕残碍程度评定量表(DHI)与Barthel量表(BI)评分无显著差异(P>0.05);治疗1周后,两组患者DHI评分降低,BI评分升高,且观察组DHI评分显著低于对照组,观察组BI评分显著高于对照组(P<0.05)。治疗前,两组急性眩晕症患者的基底动脉(BA)、左椎动脉(LVA)和右椎动脉(RVA)的血液流速均无显著差异(P>0.05);治疗1周后,两组患者BA、LVA和RVA的血液流速均明显加快,且观察组快于对照组(P<0.05)。治疗前,两组患者活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)及纤维蛋白原(FIB)均无统计学差异(P>0.05);治疗1周后,两组患者APTT和PT均升高,且观察组显著高于对照组(P<0.05);FIB均降低,且观察组显著低于对照组(P<0.05)。结论:丹红注射液联合倍他司汀治疗急性眩晕患者临床疗效良好,可提高治疗效果与患者的生活自理能力,且改善脑血流状态与凝血状态。

Objective:To investigate the effects of Danhong injection combined with betahistine on cerebral hemodynamics and coagulation indicators in patients with acute vertigo.Methods:From February 2021 to February 2023,60 patients with acute vertigo diagnosed and treated in our hospital were selected as research subjects and divided into an observation group(30 cases)and a control group(30 cases)by the random number method.The enrolled patients in both groups received routine treatment for hypotension and hypoglycemia.The control group was administered betahistine 20 mg sodium chloride injection 250 ml intravenously for 45 min.The observation group was administered an intravenous injection of Danhong injection 30 ml+250 ml sodium chloride injection for 45 min compared to the control group.The clinical efficacy of the two groups was evaluated and compared,and the degree of vertigo,indexes of blood brain flow,and coagulation indexes were compared before and after treatment.Results:After 1 week of treatment,the total effective rate of the observation group was93.33%(28/30),which was significantly higher than that of the control group[73.33%(22/40)](P<0.05).Before treatment,there was no significant difference in the dizziness handicap inventory(DHI)and Barthel index(BI)scores between the two groups(P>0.05).After 1 week of treatment,the DHI score decreased and the BI score increased in both groups.The DHI score in the observation group was significantly lower than that in the control group,and the BI score in the observation group was significantly higher than that in the control group(P<0.05).Before treatment,there were no significant differences in the blood flow velocity of the basilar artery(BA),left vertebral artery(LVA),and right vertebral artery(RVA)between the two groups(P>0.05).After 1 week of treatment,the blood flow velocity of the BA,LVA,and RVA in both groups was significantly accelerated,and the observation group was faster than the control group(P<0.05).Before treatment,there were no significant differences in activated partial thromboplastin time(APTT),prothrombin time(PT),or fibrinogen(FIB)between the two groups(P>0.05).After 1 week of treatment,APTT and PT increased in both groups,and the levels in the observation group were significantly higher than those in the control group(P<0.05).The FIB of the observation group was significantly lower than that of the control group(P<0.05).Conclusion:Danhong injection combined with betahistine has a good clinical effect in the treatment of patients with acute vertigo,which can improve the therapeutic effect and self-care ability of patients and improve cerebral blood flow and coagulation status.