睾酮与青少年分裂型人格障碍的相关性分析

目的探讨睾酮与男性青少年分裂型人格障碍(SPD)的相关性。方法采用明尼苏达多项人格测试(MMPI)对某大学3,500名男性新生进行普查,以SC尺度分值>70分、且F值在65~79作为分裂型人格特征阳性者,再经精神科主治医师使用DSM-Ⅳ分裂型人格障碍结构性访谈问卷筛选出50名SPD作为观察组。再随机选取MMPI各个临床尺度在正常范围内的学生50名为对照组。采用一般问卷、攻击性量表(AQ)、威廉姆斯创造性倾向量表、分裂型人格问卷(SPQ)对两组学生进行调查;线段方向判断测验评定视空间知觉,Stroop色-字干扰测验评定部分执行功能。采用电化学发光法测定血清游离睾酮水平。结果两组睾酮水平差异有统计学意义(P<0.05),右侧2D:4D比值即右侧食指与环指的指长比值差异有统计学意义(P<0.05)。睾酮水平与阳性分裂型维度症状呈正相关、且与怪异信念呈正相关(P<0.05);AQ中,两组总分及身体攻击、愤怒、敌意因子分比较,差异均有统计学意义(P<0.05);威廉姆斯创造性倾向量表中,两组总分及想象因子分差异有统计学意义(P<0.05);两组SPQ评分及三个主要维度即阳性分裂型、阴性分裂型、瓦解维度及总分两组差异均有统计学意义(P<0.05);线段方向判断测试数据结果,观察组正确个数得分高于对照组,差异有统计学意义(P<0.05);色-字stroop干扰测验结果:观察组与对照组正确个数得分及各类刺激反应比较,差异均无统计学意义(P>0.05)。结论男性青少年SPD睾酮水平较高。睾酮水平与BMI指数呈负相关,与好奇因子、创造性总分、阳性分裂型症状呈正相关。睾酮是影响怪异信念的首要因素,怪异信念可能是精神分裂症或SPD的早期行为特征。

Objective To investigate the changes in testosterone levels,aggression,creativity,visuospatial perception and selective attention in male adolescents with schizotypal personality disorder.And to analyze the relationship between testosterone levels and SPQ,aggression,creativity,visuospatial perception,and selective attention.Methods MMPI-566(Minnesota Multiphasic Personality Inventory)was used to screen out schizophrenia(Sc)from 3,500 male freshmen of Maritime University.The criteria of Schizotypal personality disorder(SPD)were SC>70,65<F<79,SPD received by two psychiatrist with interview structural DSM-IV for Schizotypal personality disorder.50 SPD met the criteria of DSM-IV diagnosis served as the study group,and randomly draw out 50 normal personality students as the control group.All subjects received self-made general questionnaire,Aggression questionnaire,Williams Prefer Measurement Forms and Schizotypal personality questionnaire(SPQ).The line segment direction judgment test evaluated visual spatial perception,and the Stroop color word interference test evaluated partial executive function.D2:D4 ratio was used to assess prenatal exposure levels to testosterone.Testosterone of serum were measured by Electrochemiluminescence method.Results There were significant differences between the SPD group and the control group(P<0.05)in testosterone levels.There were significant differences between the SPD group and the control group in the right 2D:4Dratio(P<0.05).In the SPD group,testosterone levels significantly positively correlated with odd beliefs in SPQ(P<0.05).In the Aggression Questionnaire,the total score and physical aggression,anger,and hostility factors of the two groups were compared,and the difference in score values was statistically significant(P<0.05).In the Williams Creativity Scale,there was a statistically significant difference in total score and imagination factor score between the two groups(P<0.05).There were statistically significant differences in the scores,total scores,and three main dimensions of the split personality questionnaire(SPQ)between the two groups(P<0.05).The results of the line segment direction judgment test showed that the correct number score of the split personality disorder group was higher than that of the control group,and the difference in score was statistically significant(P<0.05).The Stroop Test showed that under four different Stroop word color interference conditions,there was no statistically significant difference in the correct number scores and various stimulus response times between the split personality disorder group and the control group.Conclusion Male adolescents have higher levels of SPD testosterone.Testosterone levels are negatively correlated with BMI,and positively correlate with curiosity factor,total creativity score,and positive split type symptoms.Testosterone is a risk factor for SPD and Sc(schizophrenia ruler).Odd belief symptom may be is early behavior mark for Sc or SPD.