参姜止痢合剂治疗仔猪黄痢的临床疗效评价

Clinical Evaluation of Shenjiang Zhili Mixture for Treatment of Piglet Yellow Dysentery

为验证参姜止痢合剂治疗仔猪黄痢的临床疗效,从兰州周边养猪场搜集疑似病例,经流行病学调查、临床症状观察作出初步诊断,通过实验室细菌学检查进行确诊后,采用参姜止痢合剂进行治疗,观察给药后病猪精神状态、饮食和腹泻情况,采用普通血平板培养基和大肠杆菌显色培养基测定给药前后仔猪粪便中大肠杆菌的数量。结果显示,用药治疗后的仔猪精神状态明显好转或恢复正常,病猪粪便中大肠杆菌数量明显减少,3个养猪场(景泰县王德香养猪场、甘肃蟾慕农业科技有限责任公司和永登县苗中俊养猪场)的黄痢治愈率分别为87.6%、89.1%和84.1%。结果提示,参姜止痢合剂治疗仔猪黄痢效果较好,为今后研发新药提供了试验依据。

To evaluate the clinical effcacy of Shenjiang Zhili Mixture for treatment of piglet yellow dysentery,the suspected cases were chose from the pig farms around Lanzhou city.After the preliminary diagnosis by epidemiological investigation and clinical observation,piglet yellow dysentery was further confirmed by laboratory bacteriological examination.Then Shenjiang Zhili Mixture was administered to these pigs,which were observed for clinical signs including activity,diet and diarrhea.The fecal samples were also collected for examination of Escherichiacoli loads using blood agar plates and chromogenic culture.The results showed that piglets’activities were significantly improved or returned to normal after drug treatment.The cure rates of yellow dysentery in three pig farms(Wangdexiang Pig Farm in Jingtai County,Gansu Chanmu Agricultural Science and Technology Co.,Ltd.and Miaozhongjun Pig Farm in Yongdeng County)were 87.6%,89.1%and 84.1%,respectively.The E.coli loads in diseased pig feces were also significantly reduced after drug treatment.The results indicated that Shenjiang Zhili Mixture had good treatment effect on piglet yellow dysentery and would deserve for further development of a new drug.