热激同源蛋白Hsc70在病毒侵染过程中的机制研究

Mechanism of Heat Shock Cognate 70 in Viral Infections

作为一类热激蛋白家族HSP70的成员,热激同源蛋白Hsc70常常在细胞内表现为组成型表达并在ATP代谢、蛋白折叠转运、抗原呈递、细胞内吞和线粒体自噬等多个途径中参与维持细胞内环境的稳态。近年来的研究表明,Hsc70还在多种病原侵染特别是病毒感染引发的各种疾病中呈现多重角色,很多病毒病原都可以操控Hsc70完成自身复制。在本文中,我们总结了近年来Hsc70蛋白在病毒侵入、病毒胞内转运和解聚、病毒基因组复制、形态建成和宿主的抗病毒免疫等过程中的功能研究进展,可为深入理解热激蛋白及其同源蛋白家族在病毒侵染中的作用机制提供更多支撑。

As an important homologous chaperon of heat shock proteins(HSPs),Hsc70(heat shock cognate 70)often exhibits the constitutive expression and facilitates to keep the cellular environmental homeostasis through ATP metabolism,protein folding and transporting,antigen presentation,endocytosis and mitochondrial autophagy and so on.Recent studies further suggest that Hsc70 plays multiple roles in many pathogenic,especially viral infectious diseases.Some viruses manipulate Hsc70 for their self-replication.In this review,we concluded the research developments of Hsc70 on the virus attachment/entry,viral intracellular traffcking and disassembly,viral genome replication,viral morphogenesis and virus-induced host-protective immune responses,which would provide more theoretical data on the research of Hsc70 in the process of viral infections.