慢性牙周炎对支气管扩张症患者生活质量及严重程度的影响

Effect of chronic periodontitis on quality of life and severity in patients with bronchiectasis

目的:探讨慢性牙周炎对支气管扩张症患者生活质量和疾病严重程度的影响。方法:随机选择2021年4月—2023年4月长沙市第四医院收治的支气管扩张症患者80例作为研究对象,按照是否伴中重度慢性牙周炎将患者分为2组,分别为支气管扩张伴牙周炎组(n=45)和支气管扩张不伴牙周炎组(n=35)。采用支气管扩张生活质量问卷(QoL-B)调查患者的生活质量,采用支气管扩张严重程度指数(BSI)评估疾病严重程度,并检测患者血清高敏C反应蛋白(hsCRP)、肿瘤坏死因子α(TNF-ɑ)、白细胞介素6(IL-6)的水平。采用SPSS 20.0软件包对数据进行统计学分析。结果:支气管扩张伴牙周炎组QoL-B评分显著低于支气管扩张不伴牙周炎组,BSI评分显著高于支气管扩张不伴牙周炎组(P<0.05)。支气管扩张伴牙周炎组hs-CRP、TNF-ɑ、IL-6水平显著高于支气管扩张不伴牙周炎组(P<0.05)。结论:支气管扩张患者中伴有慢性牙周炎的患者在生活质量和疾病严重程度方面都表现出明显的不利影响,可能与炎症反应在2种疾病之间的共同机制有关。

PURPOSE:To investigate the effects of chronic periodontitis on the quality of life and severity of the disease in patients with bronchiectasis.METHODS:A total of 80 bronchiectasis patients admitted to The Fourth Hospital of Changsha between April 2021 and April 2023 were randomly selected.Patients were divided into two groups according to whether they had moderate to severe chronic periodontitis:bronchiectasis with periodontitis group(n=45)and bronchiectasis without periodontitis group(n=35).The Qualify of Life Questionnaire for Bronchiectasi(QoL-B)was used to assess patients'quality.The severity of the disease was assessed using the Bronchiectasis Severity Index(BSI),and serum levels of hypersensitive C-reactive protein(hsCRP),tumor necrosis factor alpha(TNF-alpha),and interleukin-6(IL-6)were detected.SPSS 20.0 software package was used for data analysis.RESULTS:The QoL-B score of bronchiectasis with periodontitis group was significantly lower than that of bronchiectasis without periodontitis group,and the BSI score was significantly higher than that of bronchiectasis without periodontitis group(P<0.05).The levels of hs-CRP,TNF-alpha and IL-6 in bronchiectasis with periodontitis were significantly higher than those in bronchiectasis without periodontitis group(P<0.05).CONCLUSIONS:Chronic periodontitis shows significant adverse effects on both quality of life and disease severity in patients with bronchiectasis,which may be related to the common mechanism of inflammatory response between the two kinds of diseases.