促愈消肿汤对运动致肱骨远端骨折患者术后骨生长及功能恢复的影响

Effect of Cuyu Xiaozhong Decoction on Postoperative Bone Growth and Functional Recovery in Patients with Exercise-induced Distal Humeral Fractures

目的:探究促愈消肿汤对运动致肱骨远端骨折患者术后血清成纤维细胞生长因子2(FGF-2)、骨形态发生蛋白7(BMP-7)水平及骨愈合状态的影响。方法:选取2021年3月至2022年9月河南省中医院收治的运动致肱骨远端骨折患者86例作为研究对象,采用随机数字法分为对照组和观察组,每组43例。对照组术后采用常规康复治疗;观察组在对照组基础上服用促愈消肿汤治疗。对比治疗后2组临床疗效及术后恢复情况,术后1 d与术后7 d时2组肘关节功能、关节活动度及血清FGF-2、BMP-7水平差异。结果:观察组临床疗效为93.02%,显著高于对照组的76.74%(P<0.05);治疗后观察组疼痛消除时间、术处消肿时间及骨折愈合时间显著短于对照组(均P<0.05);术后7 d时,观察组Mayo肘关节功能量表,关节活动度(ROM)评分以及血清FGF-2、BMP-7水平显著升高,且高于对照组(均P<0.05);术后7 d时,观察组视觉模拟评分法(VAS)得分较术后1 d时显著降低,且低于对照组(均P<0.05)。结论:运动致肱骨远端骨折患者术后服用促愈消肿汤能有效促进血清FGF-2、BMP-7水平表达上调,改善肘关节活动功能,缓解术后疼痛,加速骨折愈合。

Objective:To explore the effect of Cuyu Xiaozhong Decoction(CYXZ) on the levels of serum fibroblast growth factor 2(FGF-2),bone morphogenetic protein 7(BMP-7),and bone healing status in patients with exercise-induced distal humeral fractures after surgery.Methods:Eighty-six patients with exercise-induced distal humeral fractures treated at Henan Provincial Hospital of Traditional Chinese Medicine from March 2021 to September 2022 were enrolled and randomly divided into a control group and an observation group,with 43 cases in each group.The control group received routine rehabilitation treatment after surgery,while the observation group received CYXZ in addition to routine treatment.The clinical efficacy and postoperative recovery of the two groups were compared.Differences in elbow joint function,joint mobility,serum FGF-2,and BMP-7 levels between the two groups at 1 day and 7 days postoperatively were also compared.Results:The clinical efficacy in the observation group was 93.02%,significantly higher than 76.74% in the control group(P<0.05).The observation group showed significantly shorter times for pain relief,swelling reduction,and fracture healing than the control group(all P<0.05).At 7 days postoperatively,the Mayo Elbow Performance Score,range of motion(ROM),serum FGF-2,and BMP-7 levels in the observation group were significantly higher than those in the control group(all P<0.05).The Visual Analog Scale(VAS) score in the observation group at 7 days postoperatively was significantly lower than that at 1 day postoperatively and lower than that in the control group(all P<0.05).Conclusion:Postoperative administration of CYXZ in patients with exercise-induced distal humeral fractures effectively promotes the upregulation of serum FGF-2 and BMP-7 levels,improves elbow joint function,alleviates postoperative pain,and accelerates fracture healing.