环钻减容术联合浅层X线放射和局部注射治疗泛发性瘢痕疙瘩的临床观察

Clinical observation of trephine combined with superficial X-ray radiation and local injection in the treatment of generalized keloids

目的评价环钻减容术联合浅层X线放射和局部注射综合治疗泛发性瘢痕疙瘩的临床效果及安全性。方法纳入2020年5月—2021年5月在南方医科大学皮肤病医院就诊的5例泛发性瘢痕疙瘩患者共18个患病部位,采用环钻减容术联合浅层X线放射、局部注射曲安奈德药物进行治疗。治疗结束12个月后评估患者瘢痕疙瘩的VSS评分,与治疗前进行比较,并观察不良反应。结果患者治疗后所有部位的瘢痕疙瘩均较前变平、变软,VSS评分(4.08±1.11)显著低于治疗前(9.28±1.52),差异有统计学意义(t=16.30,P<0.001)。随访期间患者均未发生严重感染、严重过敏及皮肤溃疡。结论环钻减容术联合浅层X线放射和局部药物注射对于泛发性瘢痕疙瘩临床效果好,无明显不良反应发生。

Objective To evaluate the clinical efficacy and safety of trephine combined with superficial X-ray radiation and local injection in the treatment of generalized keloids.Methods Five patients with generalized keloids treated at Dermatology Hospital of Southern Medical University from May 2020 to May 2021 were included in this study.VSS scores were compared before and after 12-month treatments with trephine combined with superficial X-ray radiation and local injection of triamcinolone acetonide.Adverse reactions were also assessed.Results After the treatment,all scar tissue became flatter and softer.The VSS scores were significantly decreased from the baseline(4.08±1.11 vs.9.28±1.52,t=16.30,P<0.001).No severe infections,severe allergy or skin ulcers were observed during the follow-up period.Conclusion Trephine combined with superficial X-ray radiation and local injection of triamcinolone acetonide is effective and safe for keloids.