脾氨肽口服冻干粉治疗肺炎支原体肺炎患儿效果及对血清Gal-3、sB7-H3表达影响

Therapeutic effect of spleen aminopeptide oral lyophilized powder on children with mycoplasma pneumoniae pneumonia and its influence on serum Gal-3 and sB7-H3 expression

目的探讨脾氨肽口服冻干粉治疗肺炎支原体肺炎(MPP)患儿效果及对血清半乳糖凝集素-3(Gal-3)、可溶性B7-H3(sB7-H3)表达的影响。方法选取2022年8月至2023年2月厦门大学附属第一医院杏林分院收治的MPP患儿80例,采用随机数表法将其分为对照组(n=40)和研究组(n=40)。对照组行常规治疗,研究组行常规治疗+脾氨肽口服冻干粉治疗,比较两组临床疗效、症状改善情况、血清Gal-3和sB7-H3表达水平以及不良反应发生率。结果研究组治疗总有效率(95.00%)明显高于对照组(72.50%),差异有统计学意义(P<0.05);研究组临床症状消失时间、平均住院时间及血白细胞计数恢复正常时间均明显短于对照组,差异有统计学意义(P<0.05);治疗后,研究组血清Gal-3、sB7-H3水平低于对照组,差异有统计学意义(P<0.05);两组不良反应总发生率(12.50%vs.15.00%)比较,差异无统计学意义(P>0.05)。结论脾氨肽口服冻干粉可显著提高MPP患儿临床疗效,改善其临床体征,降低患儿血清Gal-3、sB7-H3表达水平,且安全性较高。

Objective To investigate the therapeutic effect of spleen aminopeptide oral lyophilized powder on children with mycoplasma pneumoniae pneumonia(MPP)and its influence on the expression of serum galectin-3(Gal-3)and soluble B7-H3(sB7-H3).Methods A total of 80 children with MPP admitted to Xinglin Branch of the First Affiliated Hospital of Xiamen University from August 2022 to February 2023 were randomly divided into the control group(n=40)and the study group(n=40)according to the random number table method.The control group received conventional treatment,and the study group received conventional treatment plus oral lyze-dried splenic peptide treatment.The clinical efficacy,symptom improvement,serum Gal-3 and sB7-H3 expression levels and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of children in the study group(95.00%)was significantly higher than that in the control group(72.50%),with a statistically significant difference(P<0.05).The time to clinical symptom disappearance,the average length of stay and the duration for white blood cell count to return to normal in the study group were significantly shorter than those in the control group,with statistically significant differences(P<0.05).After treatment,the serum levels of Gal-3 and sB7-H3 in the study group were significantly lower than those in the control group,with statistically significant differences(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(12.50%vs.15.00%)(P>0.05).Conclusion Spleen aminopeptide oral lyophilized powder can significantly increase the clinical efficacy,improve the clinical signs and reduce the expression levels of serum Gal-3 and sB7-H3 in MPP children,wi th high safety.