胺碘酮在快速性心律失常患者院前急救治疗中的应用效果

Application Effect of Amiodarone in Prehospital Emergency Treatment of Patients with Tachyarrhythmia

目的:探讨胺碘酮在快速性心律失常(TH)患者院前急救治疗中的应用效果。方法:选取2020年5月—2022年5月于河池市人民医院接受急救的120例TH患者作为研究对象,采用随机数字表法分为对照组与观察组,各60例。两组均行常规院前急救诊疗措施,对照组给予普罗帕酮治疗,观察组给予胺碘酮治疗。比较两组治疗效果。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.015)。治疗前,两组心率(HR)、收缩压(SBP)、舒张压(DBP)比较,差异无统计学意义(P>0.05);治疗后,两组HR、SBP、DBP均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组二尖瓣舒张早期/晚期峰值流速(E/A)、左室射血分数(LVEF)、心输出量(CO)水平比较,差异无统计学意义(P>0.05);治疗后,两组E/A、LVEF高于治疗前,且观察组高于对照组;两组CO水平高于治疗前,但观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:胺碘酮在TH患者院前急救治疗中的应用效果显著,可改善生命体征、心功能,安全性较高。

Objective:To explore the application effect of amiodarone in prehospital emergency treatment of patients with tachyarrhythmia(TH).Methods:A total of 120 TH patients who received emergency treatment in the People's Hospital of Hechi from May 2020 to May 2022 were selected as the study subjects.They were divided into control group and observation group according to random number table method,with 60 cases in each group.Both groups were given routine prehospital emergency diagnosis and treatment measures,the control group was treated with propafenone,and the observation group was treated with amiodarone.The treatment effects were compared between the two groups.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.015).Before treatment,there was no significant difference in heart rate(HR),systolic blood pressure(SBP)and diastolic blood pressure(DBP)between the two groups(P>0.05);After treatment,HR,SBP and DBP in two groups were lower than those before treatment,and these indexes in the observation group were lower than those in the control group,with a statistically significant difference(P<0.05).Before treatment,there was no significant difference in the levels of peak early/late diastolic mitral inflow velocity(E/A),left ventricular ejection fraction(LVEF)and cardiac output(CO)between the two groups(P>0.05);After treatment,the E/A and LVEF levels in the two groups were higher than those before treatment,and these levels in the observation group were higher than those in the control group;the CO levels in the two groups were higher than those before treatment,but the levels in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Amiodarone has a significant application effect in the prehospital emergency treatment of TH patients,and can improve vital signs and cardiac function,and has a high safety.