盐酸倍他司汀片治疗慢性脑供血不足头晕的效果观察

Effect Observation of Betahistine Hydrochloride Tablets in Treatment of Dizziness Caused by Chronic Cerebral Circulation Insufficiency

目的:探讨盐酸倍他司汀片治疗慢性脑供血不足头晕的效果。方法:选取2020年1月—2022年1月赤壁市人民医院收治的慢性脑供血不足头晕患者90例作为研究对象,按照随机数字表法分为对照组和观察组,各45例。对照组采用盐酸氟桂利嗪胶囊治疗,观察组采用盐酸倍他司汀片治疗。比较两组治疗效果、脑血流速度、血液流变学指标、不良反应发生情况。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.026)。治疗前,两组左椎动脉(LVA)、右椎动脉(RVA)、基底动脉(BA)血流速度比较,差异无统计学意义(P>0.05);治疗后,两组LVA、RVA、BA血流速度高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗前,两组血浆黏度、血细胞比容、纤维蛋白原比较,差异无统计学意义(P>0.05);治疗后,两组血浆黏度、血细胞比容、纤维蛋白原水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:盐酸倍他司汀片治疗慢性脑供血不足头晕的效果显著,可改善患者脑血流速度、血液流变学指标,且用药安全性较高。

Objective:To explore the effect of betahistine hydrochloride tablets in treatment of dizziness caused by chronic cere⁃bral circulation insufficiency.Methods:From January 2020 to January 2022,90 patients with dizziness caused by chronic cerebral circulation insufficiency admitted to Chibi People's Hospital were selected as the study subjects.They were divided into control group and observation group according to random number table method,with 45 patients in each group.The control group was treated with flunarizine hydrochloride capsules,and the observation group was treated with betahistine hydrochloride tablets.The therapeutic effect,cerebral blood flow velocity,hemorheology index and adverse reactions of the two groups were compared.Re⁃sults:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.026).Before treatment,there was no statistically significant difference in left vertebral artery(LVA),right vertebral artery(RVA),basilar artery(BA)blood flow velocities between the two groups(P>0.05);After treatment,the LVA,RVA and BA blood flow velocities in the two groups were higher than those before treatment,and these indexes in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in plasma viscosity,hematocrit and fibrinogen between the two groups(P>0.05);After treatment,the plasma viscosity,hematocrit and fibrinogen levels in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Con⁃clusion:The betahistine hydrochloride tablets have significant effects in treatment of dizziness caused by chronic cerebral circula⁃tion insufficiency,and can improve cerebral blood flow velocity and hemorheology indexes,with high drug safety.