改良LIFT手术联合自体富血小板PRP凝胶技术治疗肛瘘的临床研究

Clinical Study of Modified LIFT Surgery Combined with Autologous Platelet-Rich PRP Gel in the Treatment of Anal Fistula

目的:探讨改良括约肌间瘘管结扎术(LIFT)手术联合自体富血小板PRP凝胶技术治疗肛瘘的临床疗效。方法:随机将2021年5月至2023年5月在我院接受治疗的62例肛瘘患者分为对照组和观察组,31例一组。对照组采用改良LIFT手术治疗,观察组予以改良LIFT手术联合自体富血小板PRP凝胶技术治疗。随访两个月,比较两组住院时间,创面愈合时间,创面瘢痕面积,临床疗效,术后疼痛评分,肛门功能评分,并发症发生率。结果:观察组的住院时间和创面愈合时间均短于对照组,创面瘢痕面积少于对照组(P<0.05)。观察组治疗有效率为96.77%,高于对照组的80.65%(P<0.05)。观察组术后1天、7天VAS评分及术后1、2个月Wexner评分均低于对照组(P<0.05)。观察组术后并发症发生为6.45%,低于对照组的25.81%(P<0.05)。结论:肛瘘采用改良LIFT手术联合自体富血小板PRP凝胶技术治疗效果突出,可以缓解术后疼痛,改善肛门功能,减少并发症,促进预后恢复,值得临床推广应用。

Objective:To investigate the clinical effect of improved sphincter fistulae ligation(LIFT)combined with platelet-rich PRP gel technique in the treatment of anal fistula.Methods:A total of 62 patients with anal fistula were randomly divided into control group and Observation Group,31 cases in each group.All the patients were 2021 from May to May 2023 in our hospital.The patients in the control group were treated with modified LIFT operation,while the patients in the observation group were treated with modified LIFT operation combined with PRP gel.Two months follow-up,the two groups were compared in terms of hospital stay,wound healing time,wound scar area,clinical efficacy,postoperative pain score,anal function score,and complication rate.Results:The time of hospitalization and wound healing in the observation group was shorter than that in the control group,and the area of wound scar was less than that in the control group(P<0.05).The effective rate in the observation group was 96.77%,which was higher than that in the control group(P<0.05).The VAS score on the 1st and 7th day after operation and the Wexner score on the 1st and 2nd month after operation in the observation group were lower than those in the control group(P<0.05).The incidence of postoperative complications in the observation group was 6.45%,which was lower than that in the control group(P<0.05).Conclusion:The improved LIFT operation combined with PRP gel is effective in the treatment of anal fistula,which can relieve postoperative pain,improve anal function,reduce complications and promote the recovery of prognosis,it is worthy of clinical application.