摘要
严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的新型冠状病毒感染(COVID-19)传播迅速,影响范围广,除了肺部并发症外还包括突发性耳聋。然而,其病理机制尚不清楚。可能的机制包括:病毒直接侵入并损伤耳蜗神经或耳蜗组织;耳蜗微血管血栓形成并导致耳蜗血管阻塞;病毒引起细胞因子风暴,导致耳蜗炎症。研究SARS-CoV-2作为突发性感音神经性听力损失病因的作用,可能为疾病的早期诊断、制定治疗策略以最大限度地提高临床恢复和避免不良反应提供机会。
Coronavirus disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can spread rapidly with broad impacts,including sudden deafness in addition to pulmonary complications.However,the pathological mechanism remains unclear.Possible mechanisms may include:direct virus invasion and damage of the cochlear nerve or cochlea,cochlear microvascular thrombosis and vascular obstruction,and cytokine storms leading to cochlear inflammation.Understanding the role of SARS-CoV-2 as a cause of sudden deafness may provide opportunities for early diagnosis and development of treatment strategies to maximize clinical recovery while minimizing side effects.
作者
陈晓奉
谢兰丰
CHEN Xiaofeng;XIE Lanfeng(Department of Infectious Diseases,Shanghai Tongren Hospital,Shanghai 200336,China)
出处
《中华耳科学杂志》
CSCD
北大核心
2024年第1期150-153,共4页
Chinese Journal of Otology
基金
感染性疾病防治团队疫情防控创新团队(YQFKCXTD202001)。