实验动物设施智能控制系统建设与运行经验探讨:以深圳市药品检验研究院为例

Discussion on the Construction and Operational Experience of Intelligent Control Systems for Laboratory Animal Facilities:Shenzhen Institute for Drug Control as an Example

智能控制系统能够有力地辅助实验动物设施建设和管理,提高设施运行效率,保证动物实验结果的可靠性,并大幅节省人力资源。深圳市药品检验研究院实验动物设施智能控制系统于2021年4月建成,智能控制系统主要包括动物实验室智能化管理平台和动物实验室信息管理系统;其中,动物实验室智能化管理平台通过建筑设备管理系统对文丘里阀、电动风阀、电动水阀、蒸汽加湿阀等进行控制,以调节房间环境温度、湿度、压力等参数,同时通过环境监测系统对各环境参数进行在线监控;另外,自动照明控制系统、全高清视频监控系统、自动门禁和自动门系统、独立通气饲养系统、自动清洗系统、废气自动处理系统、集中供气系统、仪器参数实时监测系统等提升了实验室智能化水平;而动物实验信息管理系统将检验、仪器设备、人员、文件、标准物质、试剂、检验标准、图书、记录、科研管理、相关申请、质量管理、查询统计等信息高度集成;在实验动物工作方面,还开发了动物管理模块,实现了实验动物管理的全面信息化,同时还通过动物实验电子实验记录实现了天平校验、样品质量、动物体重等数据的实时采集和记录。总之,深圳市药品检验研究院动物实验室综合运用各类智能化系统,实现了实时在线控制和监测,提高了工作效率,保障了设施高效高质量运行,各项参数均符合标准规定,各项检验和科研工作均顺利开展,运行3年以来取得了很好的效果。本文以深圳市药品检验研究院实验动物设施建设和管理运行情况为例,从设施规模、功能、智能化管理系统、信息化管理系统等方面进行介绍,为国内同类型实验动物设施实现智能化控制提供参考。

Intelligent control systems can effectively assist in the construction and management of laboratory animal facilities,improving operational efficiency,ensuring the reliability of animal experimental results,and significantly saving human resources.The intelligent control system for laboratory animal facilities at Shenzhen Institute for Drug Control was completed in April 2021.It includes an intelligent management platform and an information management system for animal laboratories.The intelligent management platform regulates room environment parameters such as temperature,humidity,and pressure through building equipment management system,controlling devices such as the Venturi valve,electric air valve,electric water valve,and steam humidification valve.At the same time,various environmental parameters are monitored online through the environmental monitoring system.The laboratory’s intelligence is further enhanced by systems such as automatic lighting control,full HD video monitoring,automatic access control and door system,independent ventilation and feeding,automatic cleaning,automatic exhaust gas treatment,centralized gas supply,and real-time instrument parameter monitoring.The information management system for animal laboratories integrates inspection,instrument and equipment,personnel,documents,standard substances,reagents,inspection standards,books,records,scientific research management,relevant applications,quality management,and query statistics.For animal experimentation,a management module has been developed to achieve a comprehensive digitization of animal management.Furthermore,real-time collection and recording of data such as balance calibration,sample quality,and animal weight are facilitated through electronic experimental recording.In summary,the Animal Laboratory of Shenzhen Institute for Drug Control has extensively utilized intelligent systems to achieve real-time online control and monitoring,improve efficiency,ensure high-quality facility operation,and meet standard requirements.Smooth execution of all inspection and research activities has been achieved over the past three years.This paper provides insights into the construction,management,and operation of laboratory animal facilities at Shenzhen Institute for Drug Control,offering guidance for the implementation of intelligent control in similar facilities across China.