新型超分子水杨酸技术治疗玫瑰痤疮的临床研究

Clinical study of novel supramolecular salicylic acid technique in the treatment of acne rosacea

目的探索30%超分子水杨酸治疗玫瑰痤疮的疗效及安全性。方法选择2019~2021年就诊的165例诊断为玫瑰痤疮的患者作为研究对象,随机分为对照组和观察组。其中观察组85例,行传统方案结合超分子水杨酸治疗,并外用皮肤修复保湿剂;对照组80例,采用传统方案治疗。分别对两组患者的治疗效果、不良反应发生率进行统计。结果治疗前两组患者面部斑点、红色区和毛孔情况比较无统计学差异(P>0.05),治疗后两组患者上述指标均好转,且观察组优于对照组(P<0.05)。观察组治疗总有效率97.65%,显著高于对照组的85%(P<0.05)。观察组不良反应发生率为17.65%,显著低于对照组的35%(P<0.05)。结论超分子水杨酸联合传统药物治疗玫瑰痤疮效果显著、不良反应发生率低,可作为玫瑰痤疮的辅助治疗措施推广应用。

Objective To explore the efficacy and safety of 30%supramolecular salicylic acid in the treatment of acne rosacea.Methods A total of 165 patients diagnosed with rosacea from 2019 to 2021 were selected and randomly divided into control group and observation group.Among them,85 patients in the observation group received traditional treatment combined with supramolecular salicylic acid and skin repair moisturizer.The control group of 80 patients was treated with traditional regimen.The therapeutic effect and incidence of adverse reactions were statistically analyzed in the two groups.Results Before treatment,there were no statistical differences in facial spots,red areas and pores between the two groups(P>0.05),and after treatment,the above indexes were improved,and the observation group was better than the control group(P<0.05).The total effective rate of the observation group was 97.65%,which was significantly higher than that of the control group(85%,P<0.05).The incidence of adverse reactions in observation group was 17.65%,which was significantly lower than that in control group(35%,P<0.05).Conclusion Supramolecular salicylic acid combined with traditional drugs has significant effect and low incidence of adverse reactions in the treatment of rosacea,and can be used as an adjuvant therapy for rosacea.